Publication Name	World Journal of Gastroenterology
Manuscript ID	36574
Country	China

Received	2017-10-09 03:37
Peer-Review Started	2017-10-09 08:13
To Make the First Decision	2017-10-25 01:03
Return for Revision	2017-10-25 09:17
Revised	2017-11-15 11:13
Second Decision	2017-11-27 10:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-27 20:26
Articles in Press	2017-11-27 20:26
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-04 22:39
Typeset the Manuscript	2018-01-15 08:08
Publish the Manuscript Online	2018-01-19 09:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Genetics & Heredity
Manuscript Type	Basic Study
Article Title	circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling
Manuscript Source	Unsolicited Manuscript
All Author List	Xing-Ya Guo, Fang Sun, Jian-Neng Chen, Yu-Qin Wang, Qin Pan and Jian-Gao Fan
ORCID	Author(s) ORCID Number Xing-Ya Guo http://orcid.org/0000-0002-2644-5126 Fang Sun http://orcid.org/0000-0002-6688-4676 Jian-Neng Chen http://orcid.org/0000-0002-0728-0813 Yu-Qin Wang http://orcid.org/0000-0003-2894-6220 Qin Pan http://orcid.org/0000-0001-5855-4952 Jian-Gao Fan http://orcid.org/0000-0001-7443-5056
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Plan ‘Precision Medicine Research’ 2017YFSF090203 National Natural Science Foundation of China 81070346 National Natural Science Foundation of China 81270492 National Natural Science Foundation of China 81470859 National Natural Science Foundation of China 81270491 National Natural Science Foundation of China 81470840 State Key Development Program for Basic Research of China 2012CB517501 100 Talents Program XBR2011007h Program of the Committee of Science and Technology 09140903500
Corresponding Author	Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn
Key Words	Hepatocytes; Steatosis; circRNA_0046366; miR-34a; Peroxisome proliferator-activated receptor α
Core Tip	circRNA_0046366, which demonstrated ex­pression loss in HepG2-based hepatocellular steatosis, exerts antagonistic effect on miR-34a activity. miR-34a inactivation abrogates its inhibitory role against peroxisome proliferator-activated receptor (PPAR)α, and then rescues the PPARα level. PPARα restoration further improves the expression of downstream genes [i.e. carnitine palmitoyltransferase 1A (CPT1A) and solute-carrier family 27A (SLC27A)], at both transcriptional and translational levels, which are associated to triglyceride metabolism. In conclusion, the rebalancing of lipid homeostasis down-regulates triglyceride content, and attenuates the hepatocellular steatosis.
Publish Date	2018-01-19 09:46
Citation	Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337
URL	http://www.wjgnet.com/1007-9327/full/v24/i3/323.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i3.323

Full Article (PDF)	WJG-24-323.pdf
Full Article (Word)	WJG-24-323.doc
Manuscript File	36574-Review.doc
Answering Reviewers	36574-Answering reviewers.pdf
Audio Core Tip	36574-Audio core tip.mp3
Biostatistics Review Certificate	36574-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36574-Conflict-of-interest statement.pdf
Copyright License Agreement	36574-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	36574-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36574-Language certificate.pdf
Peer-review Report	36574-Peer-review(s).pdf
Scientific Misconduct Check	36574-Scientific misconduct check.pdf
Scientific Editor Work List	36574-Scientific editor work list.pdf