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1/19/2018 9:46:49 AM | Browse: 1096 | Download: 1138
Publication Name World Journal of Gastroenterology
Manuscript ID 36574
Country/Territory China
Received
2017-10-09 03:37
Peer-Review Started
2017-10-09 08:13
To Make the First Decision
2017-10-25 01:03
Return for Revision
2017-10-25 09:17
Revised
2017-11-15 11:13
Second Decision
2017-11-27 10:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-27 20:26
Articles in Press
2017-11-27 20:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-12-04 22:39
Typeset the Manuscript
2018-01-15 08:08
Publish the Manuscript Online
2018-01-19 09:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics & Heredity
Manuscript Type Basic Study
Article Title circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling
Manuscript Source Unsolicited Manuscript
All Author List Xing-Ya Guo, Fang Sun, Jian-Neng Chen, Yu-Qin Wang, Qin Pan and Jian-Gao Fan
ORCID
Author(s) ORCID Number
Xing-Ya Guo http://orcid.org/0000-0002-2644-5126
Fang Sun http://orcid.org/0000-0002-6688-4676
Jian-Neng Chen http://orcid.org/0000-0002-0728-0813
Yu-Qin Wang http://orcid.org/0000-0003-2894-6220
Qin Pan http://orcid.org/0000-0001-5855-4952
Jian-Gao Fan http://orcid.org/0000-0001-7443-5056
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Plan ‘Precision Medicine Research’ 2017YFSF090203
National Natural Science Foundation of China 81070346
National Natural Science Foundation of China 81270492
National Natural Science Foundation of China 81470859
National Natural Science Foundation of China 81270491
National Natural Science Foundation of China 81470840
State Key Development Program for Basic Research of China 2012CB517501
100 Talents Program XBR2011007h
Program of the Committee of Science and Technology 09140903500
Corresponding Author Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn
Key Words Hepatocytes; Steatosis; circRNA_0046366; miR-34a; Peroxisome proliferator-activated receptor α
Core Tip circRNA_0046366, which demonstrated ex­pression loss in HepG2-based hepatocellular steatosis, exerts antagonistic effect on miR-34a activity. miR-34a inactivation abrogates its inhibitory role against peroxisome proliferator-activated receptor (PPAR)α, and then rescues the PPARα level. PPARα restoration further improves the expression of downstream genes [i.e. carnitine palmitoyltransferase 1A (CPT1A) and solute-carrier family 27A (SLC27A)], at both transcriptional and translational levels, which are associated to triglyceride metabolism. In conclusion, the rebalancing of lipid homeostasis down-regulates triglyceride content, and attenuates the hepatocellular steatosis.
Publish Date 2018-01-19 09:46
Citation Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337
URL http://www.wjgnet.com/1007-9327/full/v24/i3/323.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i3.323
Full Article (PDF) WJG-24-323.pdf
Full Article (Word) WJG-24-323.doc
Manuscript File 36574-Review.doc
Answering Reviewers 36574-Answering reviewers.pdf
Audio Core Tip 36574-Audio core tip.mp3
Biostatistics Review Certificate 36574-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36574-Conflict-of-interest statement.pdf
Copyright License Agreement 36574-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 36574-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36574-Language certificate.pdf
Peer-review Report 36574-Peer-review(s).pdf
Scientific Misconduct Check 36574-Scientific misconduct check.pdf
Scientific Editor Work List 36574-Scientific editor work list.pdf