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Articles Published Processes
1/19/2018 9:46:49 AM | Browse: 1428 | Download: 2311
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Received |
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2017-10-09 03:37 |
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Peer-Review Started |
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2017-10-09 08:13 |
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First Decision by Editorial Office Director |
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2017-10-24 16:58 |
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Return for Revision |
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2017-10-25 09:17 |
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Revised |
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2017-11-15 11:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-11-27 10:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-11-27 20:26 |
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Articles in Press |
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2017-11-27 20:26 |
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Edit the Manuscript by Language Editor |
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2017-12-04 22:39 |
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Typeset the Manuscript |
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2018-01-15 08:08 |
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Publish the Manuscript Online |
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2018-01-19 09:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xing-Ya Guo, Fang Sun, Jian-Neng Chen, Yu-Qin Wang, Qin Pan and Jian-Gao Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan ‘Precision Medicine Research’ |
2017YFSF090203 |
| National Natural Science Foundation of China |
81070346 |
| National Natural Science Foundation of China |
81270492 |
| National Natural Science Foundation of China |
81470859 |
| National Natural Science Foundation of China |
81270491 |
| National Natural Science Foundation of China |
81470840 |
| State Key Development Program for Basic Research of China |
2012CB517501 |
| 100 Talents Program |
XBR2011007h |
| Program of the Committee of Science and Technology |
09140903500 |
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| Corresponding Author |
Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn |
| Key Words |
Hepatocytes; Steatosis; circRNA_0046366; miR-34a; Peroxisome proliferator-activated receptor α |
| Core Tip |
circRNA_0046366, which demonstrated expression loss in HepG2-based hepatocellular steatosis, exerts antagonistic effect on miR-34a activity. miR-34a inactivation abrogates its inhibitory role against peroxisome proliferator-activated receptor (PPAR)α, and then rescues the PPARα level. PPARα restoration further improves the expression of downstream genes [i.e. carnitine palmitoyltransferase 1A (CPT1A) and solute-carrier family 27A (SLC27A)], at both transcriptional and translational levels, which are associated to triglyceride metabolism. In conclusion, the rebalancing of lipid homeostasis down-regulates triglyceride content, and attenuates the hepatocellular steatosis. |
| Publish Date |
2018-01-19 09:46 |
| Citation |
Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i3/323.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i3.323 |
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