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Articles Published Processes
1/26/2018 2:31:05 AM | Browse: 1022 | Download: 1002
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Received |
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2017-10-17 01:35 |
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Peer-Review Started |
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2017-10-17 08:41 |
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To Make the First Decision |
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2017-11-08 03:15 |
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Return for Revision |
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2017-11-09 02:23 |
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Revised |
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2017-12-02 14:23 |
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Second Decision |
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2017-12-04 09:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-12-04 19:59 |
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Articles in Press |
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2017-12-04 19:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-11 16:11 |
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Publish the Manuscript Online |
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2018-01-26 02:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yuichiro Koiima, Yosuke Hirotsu, Wataru Omata, Makoto Sugimori, Shinya Takaoka, Hiroshi Ashizawa, Keiko Nakagomi, Dai Yoshimura, Kenji Hosoda, Yoji Suzuki, Hitoshi Mochizuki and Masao Omata |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yuichiro Koiima, MD, PhD, Chief Doctor, Department of Gastroenterology, Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi 400-8506, Japan. y-kojima@ych.pref.yamanashi.jp |
| Key Words |
Inflammatory bowel disease; NUDT15; Leukopenia; Mean corpuscular volume; Japanese |
| Core Tip |
Single nucleotide polymorphism (SNP) in NUDT15 c.415C > T in exon 3 affects thiopurine-induced leukopenia in Asian Crohn’s disease patients. Meanwhile, there is a report of additional three genetic variants of NUDT15 in patients with acute lymphoblastic leukemia. We evaluated the effect of these additional genetic variants of NUDT15 on inflammatory bowel disease (IBD) treated with thyopurines. The increase rate of mean corpuscular volume was higher in the variants than the wild, Mutations of NUDT15 in exon 1 also affects thiopurine-induced leukopenia in patients with IBD. To discuss thiopurine-induced leukopenia, investigating SNPs both exons 1 and exon 3 of NUDT15 is needed. |
| Publish Date |
2018-01-26 02:31 |
| Citation |
Kojima Y, Hirotsu Y, Omata W, Sugimori M, Takaoka S, Ashizawa H, Nakagomi K, Yoshimura D, Hosoda K, Suzuki Y, Mochizuki H, Omata M. Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines. World J Gastroenterol 2018; 24(4): 511-518 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i4/511.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i4.511 |
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