Publication Name	World Journal of Gastroenterology
Manuscript ID	36631
Country	Germany

Received	2017-10-28 06:49
Peer-Review Started	2017-10-28 09:37
To Make the First Decision	2017-11-15 01:25
Return for Revision	2017-11-16 11:40
Revised	2017-12-01 08:28
Second Decision	2017-12-04 08:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-12-04 19:50
Articles in Press	2017-12-04 19:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-15 08:10
Publish the Manuscript Online	2018-01-19 09:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Beneficial long term effect of a phosphodiesterase-5-inhibitor in cirrhotic portal hypertension: A case report with 8 years follow-up
Manuscript Source	Unsolicited Manuscript
All Author List	Peter Deibert, Adhara Lazaro, Zoran Stankovic, Denise Schaffner, Martin Rössle and Wolfgang Kreisel
ORCID	Author(s) ORCID Number Peter Deibert http://orcid.org/0000-0002-3291-884X Adhara Lazaro http://orcid.org/0000-0001-9023-1387 Zoran Stankovic http://orcid.org/0000-0001-6265-3072 Denise Schaffner http://orcid.org/0000-0001-6173-9288 Martin Rössle http://orcid.org/0000-0002-1358-9163 Wolfgang Kreisel http://orcid.org/0000-0001-6884-0135
Funding Agency and Grant Number
Corresponding Author	Wolfgang Kreisel, MD, Professor, Department of Internal Medicine, University of Freiburg, Hugstetter Str. 55, Freiburg 79106, Germany. wolfgang.kreisel@uniklinik-freiburg.de
Key Words	Portal hypertension; Phosphodiesterase-5; Liver hemodynamics; Doppler sonography; Magnetic resonance imaging; Liver cirrhosis
Core Tip	Non-selective beta-blockers are the mainstay of medical therapy for portal hypertension in liver cirrhosis. Inhibitors of phosphodiesterase-5 (PDE-5) reduce portal pressure in the acute setting by > 10%. This is the first report of a patient with liver cirrhosis showing that in long-term treatment with a PDE-5-inhibitor the positive effect on liver hemodynamics is maintained thus preventing further variceal bleeding.
Publish Date	2018-01-19 09:46
Citation	Deibert P, Lazaro A, Stankovic Z, Schaffner D, Rössle M, Kreisel W. Beneficial long term effect of a phosphodiesterase-5-inhibitor in cirrhotic portal hypertension: A case report with 8 years follow-up. World J Gastroenterol 2018; 24(3): 438-444
URL	http://www.wjgnet.com/1007-9327/full/v24/i3/438.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i3.438

Full Article (PDF)	WJG-24-438.pdf
Full Article (Word)	WJG-24-438.doc
Manuscript File	36631-Review.docx
Answering Reviewers	36631-Answering reviewers.pdf
Audio Core Tip	36631-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	36631-Conflict-of-interest statement.pdf
Copyright License Agreement	36631-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	36631-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	36631-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Peer-review Report	36631-Peer-review(s).pdf
Scientific Editor Work List	36631-Scientific editor work list.pdf