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Articles Published Processes
2/6/2018 3:22:41 AM | Browse: 1124 | Download: 1767
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Received |
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2017-10-18 05:49 |
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Peer-Review Started |
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2017-10-18 08:12 |
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To Make the First Decision |
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2017-11-08 03:21 |
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Return for Revision |
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2017-11-09 01:29 |
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Revised |
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2017-11-17 12:02 |
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Second Decision |
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2017-11-27 09:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-27 20:17 |
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Articles in Press |
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2017-11-27 20:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-12-03 01:49 |
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Typeset the Manuscript |
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2018-01-31 10:09 |
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Publish the Manuscript Online |
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2018-02-06 03:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical utility of hepatitis B surface antigen kinetics in treatment-naïve chronic hepatitis B patients during long-term entecavir therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tien-Ching Lin, Yen-Cheng Chiu, Hung-Chih Chiu, Wen-Chun Liu, Pin-Nan Cheng, Chiung-Yu Chen, Ting-Tsung Chang and I-Chin Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
I-Chin Wu, MD, PhD, Assistant Professor, Department of Internal Medicine, National Cheng Kung University Hospital, No.138, Sheng-Li Road, North District, Tainan 70403, Taiwan. wichin@mail.ncku.edu.tw |
| Key Words |
Chronic hepatitis B; Entecavir; Hepatitis B e antigen; Hepatitis B surface antigen; Kinetics |
| Core Tip |
Baseline hepatitis B surface antigen (HbsAg) levels could be used to predict virological, serological, and biochemical responses during entecavir therapy. HBeAg-positive non-cirrhotic patients had the highest HBsAg levels at the baseline and throughout entecavir treatment, and had the highest HBsAg decrease rates during the first year of entecavir treatment. HBsAg levels decrease slowly during years of treatment. Therefore, HBsAg could be checked at 1-year interval if hepatitis B virus DNA remains undetectable. A rapid HBsAg decline per se did not guarantee better patient outcomes. In the interpretation of HBsAg changes, HBsAg levels and decrease rates should be considered together according to disease status. |
| Publish Date |
2018-02-06 03:22 |
| Citation |
Lin TC, Chiu YC, Chiu HC, Liu WC, Cheng PN, Chen CY, Chang TT, Wu IC. Clinical utility of hepatitis B surface antigen kinetics in treatment-naïve chronic hepatitis B patients during long-term entecavir therapy. World J Gastroenterol 2018; 24(4): 725-736 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i6/725.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i6.725 |
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