| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target DUSP1
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dou Dou, Yan-Fen Shi, Qing Liu, Jie Luo, Ji-Xi Liu, Meng Liu, Ying-Ying Liu, Yuan-Liang Li, Xu-Dong Qiu and Huang-Ying Tan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81673763 |
|
| Corresponding Author |
Huang-Ying Tan, PhD, Professor, Department of Integrative Oncology, China-Japan Friendship Hospital, No.2 Yinghua street, Beijing 100029, China. tanhuangying@263.net |
| Key Words |
microRNA; type 1 g-NEN; neuroendocrine neoplasm; recurrence |
| Core Tip |
In this study, we have innovatively used chip technology to study microRNAs in type 1 gastric neuroendocrine neoplasms. We found miR-202-3p was extraordinarily upregulated in the tumours compared to the control samples. Interestingly, although miR-202 belongs to let-7, a famous cancer-suppressing family, some studies have reported its oncogenic potential in some tumours. Then, we found that DUSP1 could be a target gene of miR-202-3p and was closely related to tumour occurrence and development. Finally, we successfully showed that the miR-202-3p directly regulated DUSP1 in tool cells. |
| Publish Date |
2018-01-31 01:17 |
| Citation |
Dou D, Shi YF, Liu Q, Luo J, Liu JX, Liu M, Liu YY, Li YL, Qiu XD, Tan HY. Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target DUSP1. World J Gastroenterol 2018; 24(5): 573-582 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i5/573.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i5.573 |
