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Articles Published Processes
2/9/2018 7:24:30 AM | Browse: 970 | Download: 1789
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Received |
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2017-10-29 22:27 |
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Peer-Review Started |
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2017-10-30 08:19 |
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To Make the First Decision |
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2017-11-15 01:23 |
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Return for Revision |
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2017-11-16 07:55 |
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Revised |
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2017-12-25 11:48 |
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Second Decision |
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2018-01-15 08:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-15 20:38 |
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Articles in Press |
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2018-01-15 20:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-01-20 11:32 |
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Typeset the Manuscript |
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2018-02-08 08:04 |
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Publish the Manuscript Online |
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2018-02-09 07:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Rong Jing, Fu-Wen Luo, Xing-Ming Liu, Xiao-Feng Tian and Yun Zhou |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81600446 |
| Natural Science Foundation of Liaoning Province, China |
201102048 |
| Natural Science Foundation of Dalian Medical Association |
WSJ/KJC-01-JL-01 |
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| Corresponding Author |
Yun Zhou, MD, Doctor, Doctor, Clinical Nutrition Department,, Second Affiliated Hospital of Dalian Medical University, No.467, Zhongshan Road, Shahekou district, Dalian 116023, Liaoning Province, China. zydy2ynutrition@126.com |
| Key Words |
fish oil; AMPK/SIRT1/autophagy; liver injury; intestinal ischemia/reperfusion |
| Core Tip |
Intestinal ischemia/reperfusion (I/R) injury is a remarkable problem in many clinical conditions. Increased evidence indicates AMPK/SIRT-1 pathway linked autophagy exhibits a protective effect in liver diseases. Fish oil (FO) emulsion improves outcomes in patients with parenteral nutrition associated liver injury. We aimed to evaluate whether FO can protect liver injury induced by intestinal I/R via the AMPK/SIRT-1/autophagy pathway. Our results indicate that FO may protect the liver against intestinal I/R induced injury through the AMPK/SIRT-1/autophagy pathway. To our knowledge, we maybe for the first time present that FO attenuated intestinal I/R induced liver injury by inducing autophagy both in vivo and in vitro through the AMPK/SIRT-1 signaling pathway. |
| Publish Date |
2018-02-09 07:24 |
| Citation |
Jing HR, Luo FW, Liu XM, Tian XF, Zhou Y. Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway. World J Gastroenterol 2018; 24(7): 833-843 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i7/833.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i7.833 |
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