| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Exploring the pathogenesis of primary biliary cholangitis by proteomics: A pilot study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chui-Wen Deng, Li Wang, Yun-Yun Fei, Chao-Jun Hu, Yun-Jiao Yang, Lin-Yi Peng, Xiao-Feng Zeng, Feng-Chun Zhang and Yong-Zhe Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81302591 |
| National Natural Science Foundation of China |
81172857 |
| National Natural Science Foundation of China |
81373188 |
| Capital Health Research and Developmentof Special |
2014-1-4011 |
| Research Special Fund for Public Welfare Industry of Health |
201202004 |
|
| Corresponding Author |
Yong-Zhe Li, MD, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Shuaifuyuan 1#, Dongcheng District, Beijing 100730, China. yongzhelipumch@126.com |
| Key Words |
Anti-mitochondrial antibody; Bioinformatics; Pathogenesis; Primary biliary cholangitis; Proteomics |
| Core Tip |
The pathogenesis of primary biliary cholangitis (PBC) is still unclear. Related studies have focused on genes, immune cells, and pathology. However, little research has been conducted to establish pathogenesis-related autoantibodies. In this study, we unravel the pathogenesis of PBC by detecting novel autoantibodies, using proteomics. Our results suggest that the dysfunction of three pathways in human intrahepatic biliary epithelial cells might be causative in the pathogenesis of antimitochondrial antibody (AMA)-negative PBC. More interestingly, we identify AMA-negative pathology as a potential misnomer, as we detected low levels of AMA in AMA-negative patient sera. Comprehensive research is needed to confirm these observations. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Deng CW, Wang L, Fei YY, Hu CJ, Yang YJ, Peng LY, Zeng XF, Zhang FC, Li YZ. Exploring pathogenesis of primary biliary cholangitis by proteomics: a pilot study. World J Gastroenterol 2017; 23(48): 8489-8499 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8489.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8489 |
