Publication Name	World Journal of Gastroenterology
Manuscript ID	3687
Country	Malaysia

Received	2013-05-15 08:24
Peer-Review Started	2013-05-15 14:32
To Make the First Decision	2013-06-09 10:16
Return for Revision	2013-06-18 12:53
Revised	2013-07-20 17:25
Second Decision	2013-08-20 10:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 12:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-04 09:46
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells
Manuscript Source	Invited Manuscript
All Author List	Saravana Kumar Jaganathan, Eko Supriyanto and Mahitosh Mandal
Funding Agency and Grant Number	Funding Agency Grant Number Universiti Teknologi Malaysia, Malaysia for providing Visiting Research Fellowship
Corresponding Author	Dr. Saravana Kumar Jaganathan, IJ N-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com
Key Words	Honey; Apoptosis; Rhodamine-123; Sub-G1; Merocyanine; p-Coumaric acid; Reactive oxygen species
Core Tip	This article describes apoptotic effect of p-Coumaric acid, one of the phenolic components of honey, against colon cancer cells. p-Coumaric acid treatment resulted in the inhibition of proliferation and colony forming ability of human colorectal carcinoma (HCT-15) and HT 29 cells. Major events associated with growth-inhibition are increasing reactive oxygen species generation, increasing lipid layer breaks and a fall in Mitochondrial membrane potential. Further, membrane blebbing and shrinkage of p-Coumaric acid exposed HCT 15 cells insinuated apoptosis. Hence our results depicted that p-Coumaric acid is a prospective candidate for chemoprevention of colon cancer.
Publish Date	2013-12-18 09:53
Citation	Jaganathan SK, Supriyanto E, Mandal M. Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol 2013; 19(43): 7726-7734
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7726.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7726

Full Article (PDF)	WJG-19-7726.pdf
Manuscript File	3687-Review.doc
Answering Reviewers	3687-Answering reviewers.pdf
Copyright License Agreement	3687-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3687-Language certificate.pdf
Peer-review Report	3687-Peer reviews.pdf
Scientific Editor Work List	3687-Scientific editor work list.doc