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Articles Published Processes
1/26/2018 2:31:05 AM | Browse: 961 | Download: 1634
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Received |
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2017-10-30 14:34 |
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Peer-Review Started |
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2017-10-31 07:09 |
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To Make the First Decision |
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2017-11-22 01:02 |
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Return for Revision |
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2017-11-27 06:36 |
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Revised |
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2017-12-20 11:25 |
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Second Decision |
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2017-12-26 11:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-12-26 19:21 |
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Articles in Press |
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2017-12-26 19:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-01-01 23:54 |
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Typeset the Manuscript |
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2018-01-22 08:50 |
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Publish the Manuscript Online |
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2018-01-26 02:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Retrospective Study |
| Article Title |
Positron emission tomography combined with computed tomography finding: Low glucose metabolism in hepatocellular carcinoma with GPC3 expression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You-Cai Li, Chuan-Sheng Yang, Wen-Lan Zhou, Hong-Sheng Li, Yan-Jiang Han, Quan-Shi Wang and Hu-Bing Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81371591 |
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| Corresponding Author |
Hu-Bing Wu, PhD, Associate Professor, NanFang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. wuhbym@163.com |
| Key Words |
Hepatocellular carcinoma; Glypican-3; 18F-FDG; Maximum standard uptake value; T/NT ratio; Glucose metabolism; Glucose transporter 1 |
| Core Tip |
Present study demonstrated glypican-3 (GPC3) expression was positively expressed in 67.3% of hepatocellular carcinoma (HCC) patients. GPC3 expression is found to be inversely associated with the glucose metabolism of HCC tumors in the patient study. Multivariate analysis revealed that only the glucose metabolism was significantly correlated with GPC3 expression (P < 0.05), but not GLUT1 expression, tumour differentiation and other clinical indicators (P < 0.05). Low glucose metabolism was also observed in positive GPC3-expressing HepG2 cells in cellular uptake assay. Therefore, we suggested that GPC3 may play a role in regulating glucose metabolism in HCC. |
| Publish Date |
2018-01-26 02:31 |
| Citation |
Li YC, Yang CS, Zhou WL, Li HS, Han YJ, Wang QS, Wu HB. Low glucose metabolism in hepatocellular carcinoma with GPC3 expression. World J Gastroenterol 2018; 24(4): 494-503 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i4/494.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i4.494 |
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