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Articles Published Processes
3/5/2018 11:23:39 AM | Browse: 1228 | Download: 1895
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Received |
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2017-11-09 12:54 |
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Peer-Review Started |
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2017-11-10 11:47 |
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To Make the First Decision |
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2017-12-13 02:32 |
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Return for Revision |
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2017-12-14 06:38 |
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Revised |
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2017-12-22 13:33 |
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Second Decision |
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2018-01-03 09:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-04 00:39 |
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Articles in Press |
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2018-01-04 00:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-01-20 04:00 |
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Typeset the Manuscript |
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2018-03-03 07:05 |
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Publish the Manuscript Online |
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2018-03-05 11:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Yuan Zheng, Miao Wang, Xiang-Bing Shu, Pei-Yong Zheng and Guang Ji |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81370092 |
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| Corresponding Author |
Guang Ji, MD, PhD, Chief Doctor, Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com |
| Key Words |
Autophagy; PI3K-AKT-mTOR signaling pathway; Autophagic flux; Oxidative stress; Hepatocyte injury; non-alcoholic fatty liver disease |
| Core Tip |
Non-alcoholic fatty liver disease (NAFLD), which is mainly characterized by the accumulation of lipids and energy metabolism dysfunction, is now one of the most common risk factors worldwide. As studies have demonstrated that autophagy is important in the maintenance of normal hepatocyte function and in the response to pathogenic changes, we examined the potential role of autophagy in metabolic stress-induced hepatocyte injury. The results showed that metabolic stress had dual effects on autophagy, resulting in autophagy induction and autophagic flux inhibition. The Chinese herbal formula Jiang Zhi Granule activated the autophagy process to protect against metabolic stress-induced hepatocyte injury in NAFLD. |
| Publish Date |
2018-03-05 11:23 |
| Citation |
Zheng YY, Wang M, Shu XB, Zheng PY, Ji G. Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury. World J Gastroenterol 2018; 24(9): 992-1003 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i9/992.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i9.992 |
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