Publication Name	World Journal of Gastroenterology
Manuscript ID	3698
Country	Saudi Arabia

Received	2013-05-16 08:05
Peer-Review Started	2013-05-16 14:48
First Decision by Editorial Office Director
Return for Revision	2013-07-25 16:48
Revised	2013-08-06 17:52
Publication Fee Transferred
Second Decision by Editor	2013-08-13 11:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-13 13:35
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-26 10:00
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Concepts of oxidative stress and antioxidant defense in Crohn's disease
Manuscript Source	Invited Manuscript
All Author List	Mohammed A Alzoghaibi
Funding Agency and Grant Number
Corresponding Author	Mohammed A Alzoghaibi, PhD, Department of Physiology, College of Medicine, King Saud University, Amr Ibn Al As, PO Box 2925, Riyadh 11461, Saudi Arabia. zzoghaibi@gmail.com
Key Words	Crohn's disease; Reactive oxygen species; Antioxidant enzymes; Lipid peroxide
Core Tip	Crohn's disease is associated with an imbalance, comprising increased reactive oxygen species (ROS) and decreased net antioxidant activity. A deficiency in antioxidant molecules could lead to increased levels of lipid peroxides or ROS, which could act locally or be secreted into the circulation to produce different systemic effects in the patient. Future research should address the question of whether ROS are involved in increasing the production of the different extracellular proteins by enhancing the transcriptions of certain genes using specific transcription factors.
Publish Date	2013-11-08 14:06
Citation	Alzoghaibi MA. Concepts of oxidative stress and antioxidant defense in Crohn’s disease. World J Gastroenterol 2013; 19(39): 6540-6547
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6540.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6540

Full Article (PDF)	WJG-19-6540.pdf
Manuscript File	3698-Review.doc
Answering Reviewers	3698-Answering reviewers.pdf
Copyright License Agreement	3698-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3698-Language certificate.pdf
Peer-review Report	3698-Peer reviews.pdf
Scientific Editor Work List	3698-Scientific editor work list.doc