Publication Name	World Journal of Gastroenterology
Manuscript ID	37014
Country	China

Received	2017-11-03 18:36
Peer-Review Started	2017-11-04 00:11
To Make the First Decision	2017-11-14 07:15
Return for Revision	2017-11-16 11:25
Revised	2017-11-17 15:53
Second Decision	2017-11-27 11:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-11-27 19:57
Articles in Press	2017-11-27 19:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-04 09:40
Typeset the Manuscript	2017-12-14 02:07
Publish the Manuscript Online	2017-12-20 02:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge, Ping Zhu, Xiang Liu, Sheng Wang, Guo-Xin Wang and Si-Yu Sun
ORCID	Author(s) ORCID Number Fan Yang http://orcid.org/0000-0002-5032-6450 Dong-Yan Liu http://orcid.org/0000-0002-3902-9316 Jin-Tao Guo http://orcid.org/0000-0001-5722-6359 Nan Ge http://orcid.org/0000-0002-5764-7054 Ping Zhu http://orcid.org/0000-0003-2959-3885 Xiang Liu http://orcid.org/0000-0001-7538-6786 Sheng Wang http://orcid.org/0000-0001-7194-9641 Guo-Xin Wang http://orcid.org/0000-0002-5928-3370 Si-Yu Sun http://orcid.org/0000-0002-7308-0473
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Liaoning 20170541024 Shengjing Free Researcher Project Foundation 200812
Corresponding Author	Si-Yu Sun, MD, PhD, Chief Doctor, Professor, Endoscopy Center, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Key Words	Circular RNA; Pancreatic cancer; Biomarker
Core Tip	Circular (circ)RNA, a novel kind of stable endogenous RNA, plays important roles in occurrence and progression of cancer; however, little is known about their diagnostic value in pancreatic cancer. Our study focuses on a novel circRNA -- circ-LDLRAD3. Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples, including tissue samples and plasma samples. then, clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer were analyzed. The diagnostic value of circ-LDLRAD3 was verified by a ROC curve. Our study suggests that circ-LDLRAD3 may be a new type of invasive biomarker in the diagnosis of pancreatic cancer.
Publish Date	2017-12-20 02:49
Citation	Yang F, Liu DY, Guo JT, Ge N, Zhu P, Liu X, Wang S, Wang GX, Sun SY. Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer. World J Gastroenterol 2017; 23(47): 8345-8354
URL	http://www.wjgnet.com/1007-9327/full/v23/i47/8345.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i47.8345

Full Article (PDF)	WJG-23-8345.pdf
Full Article (Word)	WJG-23-8345.doc
Manuscript File	37014-Review.docx
Answering Reviewers	37014-Answering reviewers.pdf
Audio Core Tip	37014-Audio core tip.m4a
Biostatistics Review Certificate	37014-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	37014-Conflict-of-interest statement.pdf
Copyright License Agreement	37014-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37014-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	37014-Institutional Animal Care and Use Committee Approval Form or Document.pdf
Institutional Review Board Approval Form or Document	37014-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	37014-Language certificate.pdf
Peer-review Report	37014-Peer-review(s).pdf
Scientific Misconduct Check	37014-Scientific misconduct check.pdf
Scientific Editor Work List	37014-Scientific editor work list.pdf