Publication Name	World Journal of Gastroenterology
Manuscript ID	37088
Country	China

Received	2017-11-13 08:59
Peer-Review Started	2017-11-13 10:33
To Make the First Decision	2017-11-30 05:53
Return for Revision	2017-12-03 06:27
Revised	2017-12-13 06:34
Second Decision	2017-12-19 10:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-12-20 02:14
Articles in Press	2017-12-20 02:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2017-12-25 08:22
Typeset the Manuscript	2018-01-26 05:55
Publish the Manuscript Online	2018-01-31 01:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	PIK3CA and TP53 mutations predict overall survival of stage Ⅱ/Ⅲ colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Ajian Li, Huaguang Li, Erjiang Tang, Wei Wu, Ying Chen, Huihong Jiang, Moubin Lin and Lu Yin
ORCID	Author(s) ORCID Number Ajian Li http://orcid.org/0000-0001-8242-1084 Huaguang Li http://orcid.org/0000-0002-0735-3613 Erjiang Tang http://orcid.org/0000-0002-8042-5994 Wei Wu http://orcid.org/0000-0002-9050-3255 Ying Chen http://orcid.org/0000-0001-5084-7507 Huihong Jiang http://orcid.org/0000-0002-7391-1767 Moubin Lin http://orcid.org/0000-0002-0686-688X Lu Yin http://orcid.org/0000-0002-9351-3811
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81272480 Science and Technology Commission of Shanghai Municipality 15411969900 Science and Technology Commission of Shanghai Municipality 16DZ2342200
Corresponding Author	Lu Yin, PhD, Doctor, Doctor, Surgeon, Department of General Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Shanghai 200072, China. yindalu@tongji.edu.cn
Key Words	Overall survival; Colorectal cancer; PIK3CA; TP53; 5-fluorouracil; Double mutation
Core Tip	Targeted next-generation sequencing was used to detect gene mutations rather than mutational hotspots in the present study. This manuscript is by far the first to report the predictive value of the combined mutation status of PIK3CA and TP53 in colo­rectal cancer patients receiving 5-FU-based adjuvant chemotherapy. Our data revealed that the double mutation of PIK3CA and TP53 is an independent predictive factor for overall survival in stage Ⅱ/Ⅲ patients receiving 5-FU-based chemotherapy.
Publish Date	2018-01-31 01:17
Citation	Li AJ, Li HG, Tang EJ, Wu W, Chen Y, Jiang HH, Lin MB, Yin L. PIK3CA and TP53 mutations predict overall survival of stage Ⅱ/Ⅲ colorectal cancer patients. World J Gastroenterol 2018; 24(5): 631-640
URL	http://www.wjgnet.com/1007-9327/full/v24/i5/631.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i5.631

Full Article (PDF)	WJG-24-631.pdf
Full Article (Word)	WJG-24-631.doc
Manuscript File	37088-Review.docx
Answering Reviewers	37088-Answering reviewers.pdf
Audio Core Tip	37088-Audio core tip.mp3
Biostatistics Review Certificate	37088-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	37088-Conflict-of-interest statement.pdf
Copyright License Agreement	37088-Copyright assignment.PDF
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37088-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	37088-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	37088-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate	37088-Language certificate.pdf
Supplementary Material	37088-Supplementary material.pdf
Peer-review Report	37088-Peer-review(s).pdf
Scientific Misconduct Check	37088-Scientific misconduct check.pdf
Scientific Editor Work List	37088-Scientific editor work list.pdf