Publication Name	World Journal of Hepatology
Manuscript ID	37128
Country	Spain

Received	2017-11-16 18:16
Peer-Review Started	2017-11-17 01:02
To Make the First Decision	2017-12-01 07:24
Return for Revision	2017-12-01 08:17
Revised	2017-12-13 12:21
Second Decision	2017-12-18 06:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-12-29 19:09
Articles in Press	2017-12-29 19:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-18 14:40
Publish the Manuscript Online	2018-01-26 08:09

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites
Manuscript Source	Unsolicited Manuscript
All Author List	Edilmar Alvarado-Tapias, Carlos Guarner-Argente, Elida Oblitas, Elisabet Sanchez, Silvia Vidal, Eva Román, Mar Concepción, Maria Poca, Cristina Gely, Oana Pavel, Juan Camilo Nieto, Cándido Juárez, Carlos Guarner and Germán Soriano
ORCID	Author(s) ORCID Number Edilmar Alvarado-Tapias http://orcid.org/0000-0003-2036-6133 Carlos Guarner-Argente http://orcid.org/0000-0002-8180-1488 Elida Oblitas http://orcid.org/0000-0002-6832-9975 Elisabet Sanchez http://orcid.org/0000-0002-3280-9301 Silvia Vidal http://orcid.org/0000-0002-3909-6682 Eva Román http://orcid.org/0000-0001-9084-8555 Mar Concepción http://orcid.org/0000-0003-1821-0359 Maria Poca http://orcid.org/0000-0002-0235-1395 Cristina Gely http://orcid.org/0000-0003-0144-4650 Oana Pavel http://orcid.org/0000-0003-0629-9624 Juan Camilo Nieto http://orcid.org/0000-0002-3400-1488 Cándido Juárez http://orcid.org/0000-0003-2235-9893 Carlos Guarner http://orcid.org/0000-0001-5957-9481 Germán Soriano http://orcid.org/0000-0002-9267-6811
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Salud Carlos III, Madrid, Spain PI0900357 Fondos FEDER (Fondo Europeo de Desarrollo Regional), “Una manera de hacer Europa”, European Union, and CERCA Programme, Generalitat de Catalunya "Río Hortega" fellowship grant from the Instituto de Salud Carlos III CM16/00133
Corresponding Author	Edilmar Alvarado-Tapias, MD, Research Fellow, Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, Barcelona 08025, Spain. ealvaradot@santpau.cat
Key Words	Cirrhosis; Genetic polymorphisms; Toll-like receptor 4; Bacterial infections; Ascites
Core Tip	Patients with cirrhosis present a high incidence of bacterial infections. Toll-like receptor (TLR) 4 genetic polymorphisms, particularly D299G, have been previously associated with an increased predisposition to infection in several populations. In the present study, genetic polymorphisms D299G and/or T399I of TLR4 does not seem to play a relevant role in the predisposition to develop bacterial infections or in the prognosis of cirrhotic patients with ascites. Age, serum creatinine, Child-Pugh score, previous hepatic encephalopathy and the presence of hepatocellular carcinoma were independent predictive factors of mortality during follow-up.
Publish Date	2018-01-26 08:09
Citation	Alvarado-Tapias E, Guarner-Argente C, Oblitas E, Sánchez E, Vidal S, Román E, Concepción M, Poca M, Gely C, Pavel O, Nieto JC, Juárez C, Guarner C, Soriano G. Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites. World J Hepatol 2018; 10(1): 124-133
URL	http://www.wjgnet.com/1948-5182/full/v10/i1/124.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i1.124

Full Article (PDF)	WJH-10-124.pdf
Full Article (Word)	WJH-10-124.doc
Manuscript File	37128-Review.doc
Answering Reviewers	37128-Answering reviewers.pdf
Audio Core Tip	37128-Audio core tip.m4a
Biostatistics Review Certificate	37128-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	37128-Conflict-of-interest statement.pdf
Copyright License Agreement	37128-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37128-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	37128-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	37128-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	37128-Language certificate.pdf
Peer-review Report	37128-Peer-review(s).pdf
Scientific Misconduct Check	37128-Scientific misconduct check.pdf
Scientific Editor Work List	37128-Scientific editor work list.pdf