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9/11/2014 8:39:00 PM | Browse: 596 | Download: 651
Publication Name World Journal of Gastroenterology
Manuscript ID 3715
Country/Territory South Africa
Received
2013-05-17 09:07
Peer-Review Started
2013-05-17 11:55
To Make the First Decision
2013-06-09 10:18
Return for Revision
2013-06-19 09:36
Revised
2013-06-20 23:26
Second Decision
2013-07-18 17:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-07-19 02:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-10-11 22:23
Typeset the Manuscript
2013-12-18 09:12
Publish the Manuscript Online
2014-01-14 20:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Autobiography
Article Title Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India
Manuscript Source Invited Manuscript
All Author List Deepak Gopalakrishnan, Mark Keyter, Kotacherry Trivikrama Shenoy, Kondarappassery Balakumaran Leena, Lakshmikanthan Thayumanavan, Varghese Thomas, KR Vinayakumar, Charles Panackel, Arun T Korah, Ramesh Nair and Anna Kramvis
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of South Africa, NRF GUN 65530 (to Kramvis A)
Cancer Association of South Africa
postdoctoral funding from the NRF GUN 75055
University of the Witwatersrand to Gopalakrishnan D
University of the Witwatersrand
Poliomyelitis Research Foundation
Ernst and Ethel Eriksen Trust to Keyter M
Corresponding author Anna Kramvis, Professor, Hepatitis Virus Diversity Research Programme, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa. anna.kramvis@wits.ac.za
Keywords Hepatocellular carcinoma; Cirrhosis; Chronic hepatitis; Phylogenetic analysis; Genotype; India
Core Tip This study shows the predominance of subgenotype A1 in liver disease patients in Kerala, and its high prevalence in hepatocellular carcinoma (HCC) patients. Subgenotype A1 could be more hepatocarcinogenic and HCC could develop at an earlier age, regardless of host ethnicity. The S open reading frame of subgenotype A1 isolates from Kerala clustered separately within the ''Asian'' cluster and encoded distinct subgenotype A1 amino acids. A higher frequency of G1862T was detected compared with subgenotype A1 isolates from other geographical regions. This is the first time that preS deletion mutants have been described in Indian HCC patients.
Publish Date 2014-01-14 20:11
Citation Gopalakrishnan D, Keyter M, Shenoy KT, Leena KB, Thayumanavan L, Thomas V, Vinayakumar KR, Panackel C, Korah AT, Nair R, Kramvis A. Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India. World J Gastroenterol 2013; 19(48): 9294-9306
Url http://www.wjgnet.com/1007-9327/full/v19/i48/9294.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i48.9294
Full Article (PDF) WJG-19-9294.pdf
Manuscript File 3715-Review.doc
Answering Reviewers 3715-Answering reviewers.pdf
Copyright License Agreement 3715-Copyright assignment.pdf
Institutional Review Board Approval Form or Document gopalakrishnan.pdf
Non-Native Speakers of English Editing Certificate 3715-Language certificate.pdf
Peer-review Report 3715-Peer reviews.pdf
Scientific Editor Work List 3715-Scientific editor work list.doc