| Category |
Virology |
| Manuscript Type |
Autobiography |
| Article Title |
Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Deepak Gopalakrishnan, Mark Keyter, Kotacherry Trivikrama Shenoy, Kondarappassery Balakumaran Leena, Lakshmikanthan Thayumanavan, Varghese Thomas, KR Vinayakumar, Charles Panackel, Arun T Korah, Ramesh Nair and Anna Kramvis |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of South Africa, NRF |
GUN 65530 (to Kramvis A) |
| Cancer Association of South Africa |
|
| postdoctoral funding from the NRF |
GUN 75055 |
| University of the Witwatersrand |
to Gopalakrishnan D |
| University of the Witwatersrand |
|
| Poliomyelitis Research Foundation |
|
| Ernst and Ethel Eriksen Trust |
to Keyter M |
|
| Corresponding Author |
Anna Kramvis, Professor, Hepatitis Virus Diversity Research Programme, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa. anna.kramvis@wits.ac.za |
| Key Words |
Hepatocellular carcinoma; Cirrhosis; Chronic hepatitis; Phylogenetic analysis; Genotype; India |
| Core Tip |
This study shows the predominance of subgenotype A1 in liver disease patients in Kerala, and its high prevalence in hepatocellular carcinoma (HCC) patients. Subgenotype A1 could be more hepatocarcinogenic and HCC could develop at an earlier age, regardless of host ethnicity. The S open reading frame of subgenotype A1 isolates from Kerala clustered separately within the ''Asian'' cluster and encoded distinct subgenotype A1 amino acids. A higher frequency of G1862T was detected compared with subgenotype A1 isolates from other geographical regions. This is the first time that preS deletion mutants have been described in Indian HCC patients. |
| Publish Date |
2014-01-14 20:11 |
| Citation |
Gopalakrishnan D, Keyter M, Shenoy KT, Leena KB, Thayumanavan L, Thomas V, Vinayakumar KR, Panackel C, Korah AT, Nair R, Kramvis A. Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India. World J Gastroenterol 2013; 19(48): 9294-9306 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i48/9294.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i48.9294 |
