Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	3718
Country	Italy

Received	2013-05-17 09:17
Peer-Review Started	2013-05-17 11:12
To Make the First Decision	2013-06-09 10:19
Return for Revision	2013-06-18 10:52
Revised	2013-06-20 15:58
Second Decision	2013-07-05 11:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 13:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-07-13 01:25
Typeset the Manuscript	2013-08-05 09:38
Publish the Manuscript Online	2013-08-09 16:10

ISSN	2150-5330 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Health Care Sciences & Services
Manuscript Type	Frontier
Article Title	Primary clarithromycin resistance to Helicobacter pylori: Is this the main reason for triple therapy failure?
Manuscript Source	Invited Manuscript
All Author List	Floriana Giorgio, Mariabeatrice Principi, Vincenzo De Francesco, Angelo Zullo, Giuseppe Losurdo, Alfredo Di Leo and Enzo Ierardi
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Division of Gsatroenterology, Department of Medical and Surgical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 71100 Foggia, Italy. enzo.ierardi@fastwenet.it
Key Words	Helicobacter pylori; Clarithromycin; Genotypic resistance; Phenotypic resistance; Therapy failure cost; Resistance epidemiology
Core Tip	Clarithromycin resistance is the main reason for the failure of conventional therapies for Helicobacter pylori. We evaluate the scope of the problem, as reported in literature and especially on the basis of personal data in adult and paediatric populations. Another issue is the detection of resistance using phenotypic and genotypic methods; comparison is made of the limits and advantages of these approaches. Cost/benefit analysis of unsuccessful eradication therapy is performed. Based on these considerations, the best solution in future seems likely to be the detection of resistant strains before starting treatment.
Publish Date	2013-08-09 16:10
Citation	Giorgio F, Principi M, De Francesco V, Zullo A, Losurdo G, Di Leo A, Ierardi E. Primary clarithromycin resistance to Helicobacter pylori: Is this the main reason for triple therapy failure? World J Gastrointest Pathophysiol 2013; 4(3): 43-46
URL	http://www.wjgnet.com/2150-5330/full/v4/i3/43.htm
DOI	http://dx.doi.org/10.4291/wjgp.v4.i3.43

Full Article (PDF)	WJGP-4-43.pdf
Manuscript File	3718-Review.doc
Answering Reviewers	3718-Answering reviewers.pdf
Copyright License Agreement	3718-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3718-Language certificate.pdf
Peer-review Report	3718-Peer reviews.pdf
Scientific Editor Work List	3718-Scientific editor work list.doc