Publication Name	World Journal of Cardiology
Manuscript ID	37201
Country	Japan

Received	2017-11-24 09:38
Peer-Review Started	2017-11-24 17:13
To Make the First Decision	2017-12-26 00:22
Return for Revision	2017-12-27 02:26
Revised	2018-01-12 23:45
Second Decision	2018-02-06 06:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-02-06 23:43
Articles in Press	2018-02-06 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-20 05:07
Publish the Manuscript Online	2018-03-23 10:16

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Remi Goto-Semba, Yuichi Fujii, Tomohiro Ueda, Chikage Oshita and Hiroki Teragawa
ORCID	Author(s) ORCID Number Remi Goto-Semba http://orcid.org/0000-0002-1338-2314 Yuichi Fujii http://orcid.org/0000-0002-9816-1253 Tomohiro Ueda http://orcid.org/0000-0002-3524-1619 Chikage Oshita http://orcid.org/0000-0003-3471-2543 Hiroki Teragawa http://orcid.org/0000-0002-0183-2541
Funding Agency and Grant Number
Corresponding Author	Hiroki Teragawa, FACC, FACP, FAHA, MD, PhD, Chief Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku,, Hiroshima 732-0057, Japan. hiroteraga71@gmail.com
Key Words	Vasospastic angina; Acetylcholine; Brand-name drugs; Generic drugs; Refractory chest pain
Core Tip	Calcium-channel blockers (CCBs) are the first line of therapy for vasospastic angina (VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. Switching back to the original CCB improved the patients’ condition in both cases. Both cases involved highly severe VSA. It is important for cardiologists to check whether VSA patients who have refractory angina attacks while taking a CCB are taking a brand-name or generic CCB.
Publish Date	2018-03-23 10:16
Citation	Goto-Semba R, Fujii Y, Ueda T, Oshita C, Teragawa H. Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports. World J Cardiol 2018; 10(3): 15-20
URL	http://www.wjgnet.com/1949-8462/full/v10/i3/15.htm
DOI	http://dx.doi.org/10.4330/wjc.v10.i3.15

Full Article (PDF)	WJC-10-15.pdf
CARE Checklist–2016	37201-CARE-Checklist-(2013).pdf
Manuscript File	37201-Review.docx
Answering Reviewers	37201-Answering reviewers.pdf
Audio Core Tip	37201-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37201-Conflict-of-interest statement.pdf
Copyright License Agreement	37201-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	37201-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	37201-Language certificate.pdf
Supplementary Material	37201-Supplementary-Material-revision.pdf
Peer-review Report	37201-Peer-review(s).pdf
Scientific Misconduct Check	37201-Scientific misconduct check.pdf
Scientific Editor Work List	37201-Scientific editor work list.pdf