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Articles Published Processes
3/4/2018 12:36:47 PM | Browse: 860 | Download: 858
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Received |
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2017-11-21 19:55 |
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Peer-Review Started |
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2017-11-23 04:31 |
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To Make the First Decision |
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2017-12-18 08:30 |
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Return for Revision |
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2017-12-18 12:18 |
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Revised |
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2017-12-28 08:30 |
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Second Decision |
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2018-01-23 04:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-02-06 01:57 |
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Articles in Press |
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2018-02-06 01:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-02-26 02:26 |
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Publish the Manuscript Online |
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2018-03-04 12:36 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Cell fusion in the liver, revisited
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Michela Lizier, Alessandra Castelli, Cristina Montagna, Franco Lucchini, Paolo Vezzoni and Francesca Faggioli |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant AMANDA “Alterazioni metaboliche, stress cellulari e processi neurodegenerativi” from Regione Lombardia/CNR Project to P.V. Castelli A is a recipient of a fellowship from Fondazione Nicola del Roscio |
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| Corresponding Author |
Francesca Faggioli, PhD, Research Scientist, Istituto di Ricerca Genetica e Biomedica, CNR, via Fantoli 15/16, Milan 20138, Italy. francesca.faggioli@humanitasresearch.it |
| Key Words |
Cell fusion; Hepatocytes; TdTomato; Lineage tracing; Chimeras; Extracellular vesicles |
| Core Tip |
About 70% of hepatocytes are polyploid, arising either from genome duplication without division (endoreplication) or from cell fusion. Experiments with chimeric mice containing two cell populations each bearing a different genetic marker had shown that some liver cells express markers of both genomes, suggesting that cell fusion occurred. Here, we review the data in the literature and describe new experiments using a chimeric model that confirms that cell fusion contributes to liver polyploidy. We argue that the role of cell fusion in pathological conditions, such as viral hepatitis and neoplastic transformation, is worth further study. |
| Publish Date |
2018-03-04 12:36 |
| Citation |
Lizier M, Castelli A, Montagna C, Lucchini F, Vezzoni P, Faggioli F. Cell fusion in the liver, revisited. World J Hepatol 2018; 10(2): 213-221 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i2/213.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i2.213 |
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