Publication Name	World Journal of Hepatology
Manuscript ID	37278
Country	Sweden

Received	2017-11-26 03:12
Peer-Review Started	2017-11-26 04:39
To Make the First Decision	2017-12-18 08:31
Return for Revision	2017-12-18 11:44
Revised	2018-01-13 10:10
Second Decision	2018-01-18 10:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-01-24 04:17
Articles in Press	2018-01-24 04:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-24 03:10
Publish the Manuscript Online	2018-03-04 12:36

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied
Manuscript Source	Invited Manuscript
All Author List	Rui-Dong Duan
ORCID	Author(s) ORCID Number Rui-Dong Duan http://orcid.org/0000-0002-2361-3649
Funding Agency and Grant Number
Corresponding Author	Rui-Dong Duan, MD, PhD, Professor, Gastroenterology and Nutrition Lab, Department of Clinical Sciences, Lund University, Biomedical Center B11, Lund S22184, Sweden. rui-dong.duan@med.lu.se
Key Words	Sphingomyelin; Alk-SMase; NPP7; Autotaxin; Platelet-activating factor; Cholangiocarcinoma; Liver diseases; Gallstone
Core Tip	Alkaline sphingomyelinase is an enzyme expressing in the intestinal tract and additionally human liver. It hydrolyzes sphingomyelin, platelet activating factor and lysophospholipase. In the intestinal tract, it digests dietary sphingomyelin, stimulates cholesterol absorption, and inhibits development of colon cancer. Less is known about the implications of the enzyme in liver diseases. The review summarizes the current knowledge of its roles in hepatobiliary disease and raised special topics for future investigations.
Publish Date	2018-03-04 12:36
Citation	Duan RD. Alkaline sphingomyelinase (NPP7) in hepatobiliary diseases: A field that needs to be closely studied. World J Hepatol 2018; 10(2): 246-253
URL	http://www.wjgnet.com/1948-5182/full/v10/i2/246.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i2.246

Full Article (PDF)	WJH-10-246.pdf
Full Article (Word)	WJH-10-246.doc
Manuscript File	37278-Review.docx
Answering Reviewers	37278-Answering reviewers.pdf
Audio Core Tip	37278-Audio core tip.wma
Conflict-of-Interest Disclosure Form	37278-Conflict-of-interest statement.pdf
Copyright License Agreement	37278-Copyright license agreement.pdf
Peer-review Report	37278-Peer-review(s).pdf
Scientific Misconduct Check	37278-Scientific misconduct check.pdf
Scientific Editor Work List	37278-Scientific editor work list.pdf