Publication Name	World Journal of Gastroenterology
Manuscript ID	3730
Country	Mexico

Received	2013-05-17 10:10
Peer-Review Started	2013-05-17 12:28
To Make the First Decision	2013-05-23 17:21
Return for Revision	2013-05-24 09:30
Revised	2013-06-19 06:47
Second Decision	2013-08-06 13:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-06 23:03
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-02 19:54
Typeset the Manuscript	2013-12-10 14:28
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine
Manuscript Source	Invited Manuscript
All Author List	Daniela Gordillo-Bastidas, Edén Oceguera-Contreras, Adriana Salazar-Montes, Jaime González-Cuevas, Luis Daniel Hernández-Ortega and Juan Armendáriz-Borunda
Funding Agency and Grant Number	Funding Agency Grant Number Conacyt grant 25474 (to Juan Armendáriz-Borunda)
Corresponding Author	Dr. Juan Armendáriz-Borunda, Institute of Molecular Biology in Medicine and Gene Therapy/CUCS, University of Guadalajara, Av. Juarez N 976, Centro, Guadalajara, Jalisco 44100, México. armdbo@gmail.com
Key Words	Liver fibrosis; Caffeine; Thioacetamide; Bile duct ligation; Profibrogenic genes; Proinflammatory cytokines; Antioxidant enzymes
Core Tip	This paper shows the protective effect of caffeine in the liver to the constant aggressiveness of a hepatotoxic. Here we present evidence not published before of some molecular mechanisms like inhibition of Snail-1 and activation of Nrf2 that could be involved in this beneficial effect down-regulating pro-fibrogenic genes and up-regulating antioxidant molecules.
Publish Date	2014-01-20 16:41
Citation	Gordillo-Bastidas D, Oceguera-Contreras E, Salazar-Montes A, González-Cuevas J, Hernández-Ortega LD, Armendáriz-Borunda J. Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine. World J Gastroenterol 2013; 19(47): 9020-9033
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/9020.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.9020

Full Article (PDF)	WJG-19-9020.pdf
Manuscript File	3730-Review.doc
Answering Reviewers	3730-Answering reviewers.pdf
Copyright License Agreement	3730-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3730-Language certificate.pdf
Peer-review Report	3730-Peer reviews.pdf
Scientific Editor Work List	3730-Scientific editor work list.doc