Publication Name	World Journal of Otorhinolaryngology
Manuscript ID	3731
Country	New Zealand

Received	2013-05-17 10:16
Peer-Review Started	2013-05-17 12:32
To Make the First Decision	2013-06-09 09:53
Return for Revision	2013-06-18 15:19
Revised	2013-06-27 10:40
Second Decision	2013-07-24 13:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-25 04:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-24 19:19
Publish the Manuscript Online	2013-09-06 21:03

ISSN	2218-6247 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Otorhinolaryngology
Manuscript Type	Autobiography
Article Title	Adenosine amine congener ameliorates cisplatin-induced hearing loss
Manuscript Source	Invited Manuscript
All Author List	Niliksha Gunewardene, Cindy X Guo, Ann CY Wong, Peter R Thorne and Srdjan M Vlajkovic
Funding Agency and Grant Number	Funding Agency Grant Number Action on Hearing Loss (United Kingdom)
Corresponding Author	Dr. Srdjan M Vlajkovic, MD, PhD, Department of Physiology, Section of Audiology, and Centre for Brain Research, Faculty of Medical and Health Sciences, the University of Auckland, Private Bag 92019, Auckland 1010, New Zealand. s.vlajkovic@auckland.ac.nz
Key Words	Cisplatin; Cochlea; Ototoxicity; Hearing loss; Adenosine receptors; Adenosine amine congener; Otoprotection
Core Tip	This study investigated a novel pharmacological intervention to mitigate cisplatin ototoxicity using systemic administration of a selective adenosine A1 receptor agonist adenosine amine congener (ADAC). Our study demonstrates that systemic administration of ADAC confers partial protection from cisplatin-induced ototoxicity. In rats exposed to cisplatin, ADAC ameliorated high frequency hearing loss, improved the survival of the outer hair cells and reduced apoptosis of the outer hair cells and marginal cells in the stria vascularis. This study provides support for the otoprotective role of ADAC with potential clinical benefits extending from noise-induced hearing loss to cisplatin ototoxicity.
Publish Date	2013-09-06 21:03
Citation	Gunewardene N, Guo CX, Wong ACY, Thorne PR, Vlajkovic SM. Adenosine amine congener ameliorates cisplatin-induced hearing loss. World J Otorhinolaryngol 2013; 3(3): 100-107
URL	http://www.wjgnet.com/2218-6247/full/v3/i3/100.htm
DOI	http://dx.doi.org/10.5319/wjo.v3.i3.100

Full Article (PDF)	WJO-3-100.pdf
Manuscript File	3731-Review.docx
Answering Reviewers	3731-Answering reviewers.pdf
Copyright License Agreement	3731-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	713 Approval Letter.pdf
Peer-review Report	3731-Peer reviews.pdf
Scientific Editor Work List	3731-Scientific editor work list.doc