Publication Name	World Journal of Gastroenterology
Manuscript ID	37348
Country	Germany

Received	2017-12-06 17:02
Peer-Review Started	2017-12-06 18:59
First Decision by Editorial Office Director	2018-01-16 21:23
Return for Revision	2018-01-18 06:08
Revised	2018-02-21 16:28
Publication Fee Transferred
Second Decision by Editor	2018-03-02 07:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-03-03 03:41
Articles in Press	2018-03-03 03:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-04-03 05:49
Publish the Manuscript Online	2018-04-04 13:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients
Manuscript Source	Unsolicited Manuscript
All Author List	Matthias Buechter, Paul Manka, Falko M Heinemann, Monika Lindemann, Martin Schlattjan, Ali Canbay, Guido Gerken and Alisan Kahraman
ORCID	Author(s) ORCID Number Matthias Buechter http://orcid.org/0000-0003-3394-5492 Paul Manka http://orcid.org/0000-0001-8589-7280 Falko M Heinemann http://orcid.org/0000-0002-9642-1154 Monika Lindemann http://orcid.org/0000-0001-6708-4390 Martin Schlattjan http://orcid.org/0000-0001-6639-5568 Ali Canbay http://orcid.org/0000-0001-6069-7899 Guido Gerken http://orcid.org/0000-0001-6734-5001 Alisan Kahraman http://orcid.org/0000-0002-2823-6774
Funding Agency and Grant Number
Corresponding Author	Alisan Kahraman, MD, Associate Professor, Department of Gastroenterology and Hepatology, University Hospital of Essen, Hufelandstr 55, Essen 45122, North-Rhine Westphalia, Germany. alisan.kahraman@uk-essen.de
Key Words	Acute liver failure; Autoimmune hepatitis; Drug-induced liver injury; Triggering factors; MELD-score
Core Tip	Autoimmune hepatitis is considered to mani­fest as a chronic disease. In few cases, the clinician is challenged with patients revealing acute liver failure as their first manifestation of autoimmune hepatitis (AIH). The aim of our study was to investigate features of especially these patients with focus on potential triggering factors. We identified triggering factors in half of our patients (26 out of 52 patients with acute liver failure within a total cohort of 565 AIH patients). These were drugs, viral infections, and surgery. Advanced age and high MELD-score were associated with lethal outcome. Consequently, the clinician would be well-advised to document these underlying conditions.
Publish Date	2018-04-04 13:15
Citation	Buechter M, Manka P, Heinemann FM, Lindemann M, Baba HA, Schlattjan M, Canbay A, Gerken G, Kahraman A. Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients. World J Gastroenterol 2018; 24(13): 1410-1418
URL	http://www.wjgnet.com/1007-9327/full/v24/i13/1410.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i13.1410

Full Article (PDF)	WJG-24-1410.pdf
Full Article (Word)	WJG-24-1410.doc