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3/13/2018 8:32:30 AM | Browse: 243 | Download: 137
Publication Name World Journal of Gastroenterology
Manuscript ID 37351
Country of Manuscript Source Lithuania
Received
2017-12-02 16:33
Peer-Review Started
2017-12-02 19:02
To Make the First Decision
2017-12-27 02:17
Return for Revision
2017-12-27 08:53
Revised
2018-01-02 15:06
Second Decision
2018-01-15 08:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-01-15 20:42
Articles in Press
2018-01-15 20:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-03-06 03:51
Publish the Manuscript Online
2018-03-13 08:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Vaidotas Cesna, Arturas Sukovas, Aldona Jasukaitiene, Rima Naginiene, Giedrius Barauskas, Zilvinas Dambrauskas, Saulius Paskauskas and Antanas Gulbinas
ORCID
Author(s) ORCID Number
Vaidotas Cesna http://orcid.org/0000-0003-4719-8483
Arturas Sukovas http://orcid.org/0000-0001-7007-3959
Aldona Jasukaitiene http://orcid.org/0000-0002-4606-1963
Rima Naginiene http://orcid.org/0000-0001-5770-2618
Giedrius Barauskas http://orcid.org/0000-0002-4321-7280
Zilvinas Dambrauskas http://orcid.org/0000-0003-2173-1294
Saulius Paskauskas http://orcid.org/0000-0001-9930-4124
Antanas Gulbinas http://orcid.org/0000-0002-6683-1339
Funding Agency and Grant Number
Funding Agency Grant Number
Research Council of Lithuania SEN-01/2015
Correspondence To Zilvinas Dambrauskas, MD, PhD, Academic Research, Lecturer, Professor, Surgeon, Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu st. 4, Kaunas LT-50161, Lithuania. zilvinas.dambrauskas@lsmuni.lt
Keywords Hyperthermal intraperitoneal chemotherapy; Cisplatin; Hyperthermia; Isobolograms; Gastric cancer; Pancreatic cancer; Colon cancer
Core Tip Hyperthermal intraperitoneal chemotherapy is widely used as a standard treatment option for peritoneum invading gastrointestinal cancer. Our in vitro results suggest that optimal temperature has to be taken into consideration for achieving optimal therapeutic effect. In addition to cisplatin, hyperthermia up to 43 °C does not affect the viability of AGS, Caco-2, and T3M4 cells in a synergistic manner. However, some regimens of hyperthermia and cisplatin treatment are beneficial regarding an increase in intracellular cisplatin concentration and enhancement apoptosis of gastrointestinal cancer cells.
Publish Date 2018-03-13 08:32
Citation Cesna V, Sukovas A, Jasukaitiene A, Naginiene R, Barauskas G, Dambrauskas Z, Paskauskas S, Gulbinas A. Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. World J Gastroenterol 2018; 24(10): 1072-1083
Url http://www.wjgnet.com/1007-9327/full/v24/i10/1072.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i10.1072
Full Article (PDF) WJG-24-1072.pdf
Full Article (Word) WJG-24-1072.doc
Manuscript File 37351-Review.docx
Answering Reviewers 37351-Answering reviewers.pdf
Audio Core Tip 37351-Audio core tip.m4a
Biostatistics Review Certificate 37351-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37351-Conflict-of-interest statement.pdf
Copyright License Agreement 37351-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37351-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37351-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.docx
Institutional Review Board Approval Form or Document 37351-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37351-Language certificate.pdf
Peer-review Report 37351-Peer-review(s).pdf
Scientific Misconduct Check 37351-Scientific misconduct check.pdf
Scientific Editor Work List 37351-Scientific editor work list.pdf