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Articles Published Processes
3/13/2018 8:32:30 AM | Browse: 1307 | Download: 1913
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Received |
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2017-12-02 16:33 |
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Peer-Review Started |
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2017-12-02 19:02 |
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To Make the First Decision |
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2017-12-27 02:17 |
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Return for Revision |
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2017-12-27 08:53 |
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Revised |
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2018-01-02 15:06 |
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Second Decision |
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2018-01-15 08:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-15 20:42 |
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Articles in Press |
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2018-01-15 20:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-03-06 03:51 |
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Publish the Manuscript Online |
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2018-03-13 08:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vaidotas Cesna, Arturas Sukovas, Aldona Jasukaitiene, Rima Naginiene, Giedrius Barauskas, Zilvinas Dambrauskas, Saulius Paskauskas and Antanas Gulbinas |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Council of Lithuania |
SEN-01/2015 |
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| Corresponding Author |
Zilvinas Dambrauskas, MD, PhD, Academic Research, Lecturer, Professor, Surgeon, Institute for Digestive Research, Lithuanian University of Health Sciences, Eiveniu st. 4, Kaunas LT-50161, Lithuania. zilvinas.dambrauskas@lsmuni.lt |
| Key Words |
Hyperthermal intraperitoneal chemotherapy; Cisplatin; Hyperthermia; Isobolograms; Gastric cancer; Pancreatic cancer; Colon cancer |
| Core Tip |
Hyperthermal intraperitoneal chemotherapy is widely used as a standard treatment option for peritoneum invading gastrointestinal cancer. Our in vitro results suggest that optimal temperature has to be taken into consideration for achieving optimal therapeutic effect. In addition to cisplatin, hyperthermia up to 43 °C does not affect the viability of AGS, Caco-2, and T3M4 cells in a synergistic manner. However, some regimens of hyperthermia and cisplatin treatment are beneficial regarding an increase in intracellular cisplatin concentration and enhancement apoptosis of gastrointestinal cancer cells. |
| Publish Date |
2018-03-13 08:32 |
| Citation |
Cesna V, Sukovas A, Jasukaitiene A, Naginiene R, Barauskas G, Dambrauskas Z, Paskauskas S, Gulbinas A. Narrow line between benefit and harm: Additivity of hyperthermia to cisplatin cytotoxicity in different gastrointestinal cancer cells. World J Gastroenterol 2018; 24(10): 1072-1083 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i10/1072.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i10.1072 |
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