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2/27/2018 5:35:21 AM | Browse: 781 | Download: 981
Publication Name World Journal of Gastroenterology
Manuscript ID 37358
Country/Territory China
Received
2017-12-21 08:23
Peer-Review Started
2017-12-21 09:57
To Make the First Decision
2018-01-04 06:04
Return for Revision
2018-01-04 09:26
Revised
2018-01-11 10:22
Second Decision
2018-01-18 11:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-01-18 15:06
Articles in Press
2018-01-18 15:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-02-05 03:41
Typeset the Manuscript
2018-02-23 10:37
Publish the Manuscript Online
2018-02-27 05:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma: Comparison with conventional diffusion-weighted imaging
Manuscript Source Unsolicited Manuscript
All Author List Shao-Cheng Zhu, Yue-Hua Liu, Yi Wei, Lin-Lin Li, She-Wei Dou, Ting-Yi Sun and Da-Peng Shi
ORCID
Author(s) ORCID Number
Shao-Cheng Zhu http://orcid.org/0000-0003-4553-1940
Yue-Hua Liu http://orcid.org/0000-0002-8971-5947
Yi Wei http://orcid.org/0000-0003-3993-9747
Lin-Lin Li http://orcid.org/0000-0003-2245-2983
She-Wei Dou http://orcid.org/0000-0002-8434-7751
Ting-Yi Sun http://orcid.org/0000-0003-4616-744X
Da-Peng Shi http://orcid.org/0000-0002-2561-7475
Funding Agency and Grant Number
Corresponding Author Shao-Cheng Zhu, MD, PhD, Chief Doctor, Professor, Department of Radiology, Henan Provincial People’s Hospital, No. 7, Weiwu Road, Zhengzhou 450003, Henan Province, China. 104753150948@vip.henu.edu.cn
Key Words Intravoxel incoherent motion; Diffusion-weighted imaging; Hepatocellular carcinoma; Pathological differentiation grade
Core Tip Intravoxel incoherent motion (IVIM)-based diffusion-weighted imaging (DWI) can yield diffusion and perfusion information simultaneously. The aims of this study were to compare IVIM-derived parameters with conventional DWI parameters for predicting the histological grade of hepatocellular carcinomas (HCCs) and to evaluate the correlation between the parameters and the histological grades. Sixty-two patients with surgically confirmed HCCs underwent diffusion-weighted magnetic resonance imaging with twelve b values. The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of the HCCs were statistically significant (P < 0.001). The D* and f values had no significant differences among the different histological grades of the HCCs (P > 0.05). A significant correlation was obtained between the ADC, D, and D* values and the histological grades (P < 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performances in differentiating low-grade HCCs from high-grade HCCs. These results suggested that the IVIM-DWI parameters might be useful in assessing the differentiation grades of carcinomas, which might be helpful in predicting the patient prognoses.
Publish Date 2018-02-27 05:35
Citation Zhu SC, Liu YH, Wei Y, Li LL, Dou SW, Sun TY, Shi DP. Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma: Comparison with conventional diffusion-weighted imaging. World J Gastroenterol 2018; 24(8): 929-940
URL http://www.wjgnet.com/1007-9327/full/v24/i8/929.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i8.929
Full Article (PDF) WJG-24-929.pdf
Manuscript File 37358-Review.docx
Answering Reviewers 37358-Answering reviewers.pdf
Audio Core Tip 37358-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 37358-Conflict-of-interest statement.pdf
Copyright License Agreement 37358-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 37358-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 37358-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37358-Language certificate.pdf
Peer-review Report 37358-Peer-review(s).pdf
Scientific Misconduct Check 37358-Scientific misconduct check.pdf
Scientific Editor Work List 37358-Scientific editor work list.pdf