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Articles Published Processes
2/6/2018 3:22:41 AM | Browse: 1005 | Download: 1549
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Received |
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2017-12-01 03:12 |
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Peer-Review Started |
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2017-12-01 14:02 |
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To Make the First Decision |
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2017-12-13 02:35 |
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Return for Revision |
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2017-12-14 07:06 |
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Revised |
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2017-12-19 10:15 |
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Second Decision |
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2017-12-26 11:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-12-26 19:15 |
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Articles in Press |
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2017-12-26 19:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-01-02 08:12 |
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Typeset the Manuscript |
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2018-01-31 10:08 |
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Publish the Manuscript Online |
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2018-02-06 03:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun-Lan Xu, Yu Guo, Lei Qiao, Li Ma and Yi-Yi Cheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31672435 |
| Graduate Starting Seed Fund of Northwestern Polytechnical University |
Z2017237 |
| National College Students Innovation, Experiment Program |
201610699266 |
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| Corresponding Author |
Chun-Lan Xu, PhD, Associate Professor, The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyixi Road, Xi’an 710072, Shaanxi Province, China. clxu@nwpu.edu.cn |
| Key Words |
Vasoactive intestinal peptide; Intestinal mucosal barrier; Tight junction; Toll-like receptors; Recombinant expression |
| Core Tip |
Vasoactive intestinal peptide (VIP) is a neuropeptide with potent anti-inflammatory activities. Recombinant VIP analogue (rVIPa with amino acid sequence “HSKAVFTKNYTRLRKQMAVKKYLNSILN”) with higher antimicrobial activity and stability than natural peptide was produced by an effective and low-cost production method. The current study first indicated that rVIPa could alleviated TNBS-induced colitis via TLR4/NF-κB-mediated signaling pathway. In summary, these results suggest a protective role and anti-inflammatory effect of rVIPa in inflammatory bowel disease and indicate that rVIPa has therapeutic potential for intestinal inflammatory disorders. The study contributes to identify and produce novel anti-inflammatory agents from human innate host defense mechanisms in the process of biological evolution. |
| Publish Date |
2018-02-06 03:22 |
| Citation |
Xu CL, Guo Y, Qiao L, Ma L, Cheng YY. Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats. World J Gastroenterol 2018; 24(6): 706-715 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i6/706.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i6.706 |
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