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2/6/2018 3:22:41 AM | Browse: 319 | Download: 206
Publication Name World Journal of Gastroenterology
Manuscript ID 37359
Country/Territory China
2017-12-01 03:12
Peer-Review Started
2017-12-01 14:02
To Make the First Decision
2017-12-13 02:35
Return for Revision
2017-12-14 07:06
2017-12-19 10:15
Second Decision
2017-12-26 11:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-12-26 19:15
Articles in Press
2017-12-26 19:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-01-02 08:12
Typeset the Manuscript
2018-01-31 10:08
Publish the Manuscript Online
2018-02-06 03:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Basic Study
Article Title Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats
Manuscript Source Unsolicited Manuscript
All Author List Chun-Lan Xu, Yu Guo, Lei Qiao, Li Ma and Yi-Yi Cheng
Author(s) ORCID Number
Chun-Lan Xu http://orcid.org/0000-0002-0139-5046
Yu Guo http://orcid.org/0000-0002-1652-5739
Lei Qiao http://orcid.org/0000-0003-2907-7629
Li Ma http://orcid.org/orcid.org/0000-0002-0192-6847
Yi-Yi Cheng http://orcid.org/0000-0003-2684-0588
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 31672435
Graduate Starting Seed Fund of Northwestern Polytechnical University Z2017237
National College Students Innovation, Experiment Program 201610699266
Corresponding author Chun-Lan Xu, PhD, Associate Professor, The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyixi Road, Xi’an 710072, Shaanxi, China. clxu@nwpu.edu.cn
Keywords Vasoactive intestinal peptide; Intestinal mucosal barrier; Tight junction; Toll-like receptors; Recombinant expression
Core Tip Vasoactive intestinal peptide (VIP) is a neuropeptide with potent anti-inflammatory activities. Recombinant VIP analogue (rVIPa with amino acid sequence “HSKAVFTKNYTRLRKQMAVKKYLNSILN”) with higher antimicrobial activity and stability than natural peptide was produced by an effective and low-cost production method. The current study first indicated that rVIPa could alleviated TNBS-induced colitis via TLR4/NF-κB-mediated signaling pathway. In summary, these results suggest a protective role and anti-inflammatory effect of rVIPa in inflammatory bowel disease and indicate that rVIPa has therapeutic potential for intestinal inflammatory disorders. The study contributes to identify and produce novel anti-inflammatory agents from human innate host defense mechanisms in the process of biological evolution.
Publish Date 2018-02-06 03:22
Citation Xu CL, Guo Y, Qiao L, Ma L, Cheng YY. Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats. World J Gastroenterol 2018; 24(6): 706-715
Url http://www.wjgnet.com/1007-9327/full/v24/i6/706.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i6.706
Full Article (PDF) WJG-24-706.pdf
Full Article (Word) WJG-24-706.doc
Manuscript File 37359-Review.doc
Answering Reviewers 37359-Answering reviewers.pdf
Audio Core Tip 37359-Audio core tip.mp3
Biostatistics Review Certificate 37359-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37359-Conflict-of-interest statement.pdf
Copyright License Agreement 37076-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37359-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37359-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.jpg
Institutional Review Board Approval Form or Document 37359-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37359-Language certificate.pdf
Peer-review Report 37359-Peer-review(s).pdf
Scientific Misconduct Check 37359-Scientific misconduct check.pdf
Scientific Editor Work List 37359-Scientific editor work list.pdf