Publication Name	World Journal of Gastroenterology
Manuscript ID	3738
Country	Portugal

Received	2013-05-19 10:38
Peer-Review Started	2013-05-20 12:13
To Make the First Decision	2013-07-19 08:28
Return for Revision	2013-07-20 20:14
Revised	2013-08-04 20:01
Second Decision	2013-09-05 11:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-05 12:51
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-26 19:58
Publish the Manuscript Online	2013-10-15 17:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Epidermal growth factor receptor and metastatic colorectal cancer: Insights into target therapies
Manuscript Source	Invited Manuscript
All Author List	Ramon Andrade de Mello, Andrea Marin Marques and António Araújo
Funding Agency and Grant Number
Corresponding Author	Ramon Andrade de Mello, MD, PhD, Department of Medical Oncology, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. ramondemello@gmail.com
Key Words	Colorectal cancer; Epidermal growth factor receptor; KRAS mutation; Chemotherapy; Cetuximab; Panitumumab
Core Tip	Metastatic colorectal cancer (mCRC) remains a challenge for oncologists worldwide. Despite a very aggressive disease profile, mCRC’s outcomes are improving toward last decades. Target drugs, such as cetuximab and panitumumab, acquired a main role in this scenario whether phase Ⅲ trials showed interesting results in overall survival and disease control. Thus, we will briefly in this paper discuss some issues and pitfalls concerning this framework.
Publish Date	2013-10-15 17:26
Citation	de Mello RA, Marques AM, Araújo A. Epidermal growth factor receptor and metastatic colorectal cancer: Insights into target therapies. World J Gastroenterol 2013; 19(38): 6315-6318
URL	http://www.wjgnet.com/1007-9327/full/v19/i38/6315.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i38.6315

Full Article (PDF)	WJG-19-6315.pdf
Manuscript File	3738-Review.doc
Answering Reviewers	3738-Answering reviewers.pdf
Copyright License Agreement	3738-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3738-Language certificate.pdf
Peer-review Report	3738-Peer reviews.pdf
Scientific Editor Work List	3738-Scientific editor work list.doc