Publication Name	World Journal of Gastroenterology
Manuscript ID	3739
Country	China

Received	2013-05-19 10:40
Peer-Review Started	2013-05-20 12:18
To Make the First Decision	2013-06-09 09:53
Return for Revision	2013-07-24 08:50
Revised	2013-07-24 12:04
Second Decision	2013-08-06 13:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 23:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-29 11:14
Publish the Manuscript Online	2013-09-14 11:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma
Manuscript Source	Invited Manuscript
All Author List	Guo-Dong Shan, Feng-Ling Hu, Ming Yang, Hong-Tan Chen, Wen-Guo Chen, Yun-Gui Wang, Li-Hua Chen, You-Ming Li and Guo-Qiang Xu
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Foundation of the Ministry of Health, China Medical and Health Science Foundation, Zhejiang Province, China WKJ-2009-2-021
Corresponding Author	Dr. Guo-Qiang Xu, Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Qing Chun Road 79, Hangzhou 321000, Zhejiang Province, China. xgqhangzhou@163.com
Key Words	Immunoglobulin heavy chain; T-cell receptor γ; Gene rearrangement; Primary gastric lymphoma; Endoscopic biopsy specimen
Core Tip	In 2003, a new primer system was successfully developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) and T-cell receptor (TCR) genes. This study was a prospective analysis of Ig heavy chain (IgH) and TCR-γ gene rearrangements using the new primer system and endoscopic biopsy specimens from patients with suspected primary gastric lymphoma (PGL). Our study revealed that the detection of monoclonal IgH gene rearrangements is useful for the diagnosis of PGL and for differentiating between PGL and gastric linitis plastica. Monoclonal IgH gene rearrangements may be associated with PGL staging. The sensitivity and the specificity of IgH gene rearrangements for the diagnosis of PGL were 66.7% and 96.4%, respectively.
Publish Date	2013-09-14 11:17
Citation	Shan GD, Hu FL, Yang M, Chen HT, Chen WG, Wang YG, Chen LH, Li YM, Xu GQ. Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma. World J Gastroenterol 2013; 19(34): 5727-5731
URL	http://www.wjgnet.com/1007-9327/full/v19/i34/5727.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i34.5727

Full Article (PDF)	WJG-19-5727.pdf
Manuscript File	3739-Review.doc
Answering Reviewers	3739-Answering reviewers.pdf
Copyright License Agreement	3739-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3739-Language certificate.pdf
Peer-review Report	3739-Peer reviews.pdf
Scientific Editor Work List	3739-Scientific editor work list.doc