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Articles Published Processes
3/5/2018 11:23:39 AM | Browse: 838 | Download: 1130
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Received |
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2017-12-12 17:25 |
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Peer-Review Started |
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2017-12-12 19:40 |
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To Make the First Decision |
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2018-01-17 01:28 |
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Return for Revision |
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2018-01-18 06:07 |
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Revised |
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2018-01-31 02:52 |
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Second Decision |
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2018-02-08 05:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-02-09 05:41 |
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Articles in Press |
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2018-02-09 05:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-02-23 21:22 |
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Typeset the Manuscript |
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2018-03-03 07:04 |
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Publish the Manuscript Online |
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2018-03-05 11:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Practice Study |
| Article Title |
Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Youhong Fang, Youyou Luo, Jindan Yu, Jingan Lou and Jie Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Province Medical Platform Backbone |
2017KY436 |
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| Corresponding Author |
Jie Chen, MD, Attending Doctor, Chief Doctor, Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, 3333 Bin Sheng Road, Hangzhou 310052, China, Hangzhou 310052, Zhejiang Province, China. hzcjie@zju.edu.cn |
| Key Words |
Monogenic; very-early-onset inflammatory bowel disease; primary immunodeficiency diseases; IL10; IL10R |
| Core Tip |
This study is the largest study to analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease (VEO-IBD) in China. Moreover, we characterized monogenic IBD phenotypically and genotypically through genetic testing (whole exome sequencing and targeted gene panel sequencing). We found a high proportion of monogenic IBD in the VEO-IBD group, with the most common monogenic IBD being IL10R mutation. Monogenic IBD and nonmonogenic IBD showed similar clinical features. Next-generation sequencing played an important role in the diagnosis of monogenic IBD. |
| Publish Date |
2018-03-05 11:23 |
| Citation |
Fang YH, Luo YY, Yu JD, Lou JG, Chen J. Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China. World J Gastroenterol 2018; 24(9): 1035-1045 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i9/1035.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i9.1035 |
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