ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Dysregulation of PARP1 is involved in development of Barrett’s esophagus
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Chao Zhang, Teng Ma, Tao Luo, Ang Li, Xiang Gao, Zhongao Wang and Fei Li |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81470587 |
Beijing Municipal Natural Science Foundation of China |
7162076 |
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Corresponding Author |
Fei Li, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. feili35@126.com |
Key Words |
PARP1; Barrett’s esophagus; DNA repair; Oxidative damage; Bile acids |
Core Tip |
In this study, we compared the gene expression profile in normal esophagus and Barrett’s esophagus (BE), and found that poly(ADP-ribose) polymerase 1 (PARP1) was overexpressed in BE. In a BE model, positive staining for NF-κB, γH2AX, and PAR was observed. H2O2 and bile acids (pH 4) increased the PARP1 mRNA expression level in normal esophageal epithelial cells. PARP1 inhibition could decrease the cell viability after bile acids treatment, and increased the oxidative damage, double-strand breaks, and apoptosis. Thus, our study demonstrates a novel molecular mechanism for the role of PARP1 in the process of Barrett’s metaplasia, which sheds a potential therapeutic role for PARP1 inhibitor in BE. |
Publish Date |
2018-03-05 11:23 |
Citation |
Zhang C, Ma T, Luo T, Li A, Gao X, Wang ZG, Li F. Dysregulation of PARP1 is involved in development of Barrett’s esophagus. World J Gastroenterol 2018; 24(9): 982-991 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i9/982.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i9.982 |