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3/5/2018 11:23:39 AM | Browse: 889 | Download: 1646
Publication Name World Journal of Gastroenterology
Manuscript ID 37464
Country/Territory China
Received
2017-12-09 03:28
Peer-Review Started
2017-12-09 11:03
To Make the First Decision
2017-12-20 07:30
Return for Revision
2017-12-21 09:52
Revised
2017-12-26 13:38
Second Decision
2018-01-23 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-01-23 22:45
Articles in Press
2018-01-23 22:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-01-29 13:29
Typeset the Manuscript
2018-03-03 12:12
Publish the Manuscript Online
2018-03-05 11:23
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Dysregulation of PARP1 is involved in development of Barrett’s esophagus
Manuscript Source Unsolicited Manuscript
All Author List Chao Zhang, Teng Ma, Tao Luo, Ang Li, Xiang Gao, Zhongao Wang and Fei Li
ORCID
Author(s) ORCID Number
Chao Zhang http://orcid.org/0000-0002-7143-7176
Teng Ma http://orcid.org/0000-0002-8360-1543
Tao Luo http://orcid.org/0000-0002-4641-0027
Ang Li http://orcid.org/0000-0003-4795-8374
Xiang Gao http://orcid.org/0000-0003-2297-903X
Zhongao Wang http://orcid.org/0000-0003-4436-3770
Fei Li http://orcid.org/0000-0002-1713-967X
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81470587
Beijing Municipal Natural Science Foundation of China 7162076
Corresponding Author Fei Li, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. feili35@126.com
Key Words PARP1; Barrett’s esophagus; DNA repair; Oxidative damage; Bile acids
Core Tip In this study, we compared the gene ex­pression profile in normal esophagus and Barrett’s esophagus (BE), and found that poly(ADP-ribose) polymerase 1 (PARP1) was overexpressed in BE. In a BE model, positive staining for NF-κB, γH2AX, and PAR was observed. H2O2 and bile acids (pH 4) increased the PARP1 mRNA expression level in normal esophageal epithelial cells. PARP1 inhibition could decrease the cell viability after bile acids treatment, and increased the oxidative damage, double-strand breaks, and apoptosis. Thus, our study demonstrates a novel molecular mechanism for the role of PARP1 in the process of Barrett’s metaplasia, which sheds a potential therapeutic role for PARP1 inhibitor in BE.
Publish Date 2018-03-05 11:23
Citation Zhang C, Ma T, Luo T, Li A, Gao X, Wang ZG, Li F. Dysregulation of PARP1 is involved in development of Barrett’s esophagus. World J Gastroenterol 2018; 24(9): 982-991
URL http://www.wjgnet.com/1007-9327/full/v24/i9/982.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i9.982
Full Article (PDF) WJG-24-982.pdf
Full Article (Word) WJG-24-982.doc
The ARRIVE Guidelines 37464-ARRIVE Guidelines.pdf
Manuscript File 37464-Review.doc
Answering Reviewers 37464-Answering reviewers.pdf
Audio Core Tip 37464-Audio core tip.m4a
Biostatistics Review Certificate 37464-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37464-Conflict-of-interest statement.pdf
Copyright License Agreement 37464-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37464-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37464-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 37464-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37464-Language certificate.pdf
Supplementary Material 37464-Supplementary-Material-revision.pdf
Peer-review Report 37464-Peer-review(s).pdf
Scientific Misconduct Check 37464-Scientific misconduct check.pdf
Scientific Editor Work List 37464-Scientific editor work list.pdf