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Articles Published Processes
3/13/2018 8:32:30 AM | Browse: 849 | Download: 1339
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Received |
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2017-12-11 14:43 |
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Peer-Review Started |
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2017-12-12 02:42 |
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To Make the First Decision |
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2017-12-27 02:20 |
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Return for Revision |
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2017-12-27 09:31 |
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Revised |
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2017-12-31 16:22 |
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Second Decision |
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2018-01-23 10:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-23 22:43 |
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Articles in Press |
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2018-01-23 22:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-02-07 03:32 |
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Typeset the Manuscript |
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2018-03-09 09:48 |
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Publish the Manuscript Online |
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2018-03-13 08:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shakuntala Santosh Chopade and Suneela Sunil Dhaneshwar |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Women Scientist Scheme-A (WOS-A) (DST) |
SR/WOS-A/ LS-1115/2014 |
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| Corresponding Author |
Suneela Sunil Dhaneshwar, BPharm, PhD, Professor, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune 411038, India. suneeladhaneshwar@rediffmail.com |
| Key Words |
Mycophenolic acid; Mutual prodrug; Inflammatory bowel disease; Mycophenolate mofetil |
| Core Tip |
Mycophenolic acid (MPA), an immunosuppressant and its morpholinoethyl ester prodrug: mycophenolate mofetil are under investigation for the treatment of inflammatory bowel disease (IBD). Diarrhea and local gut toxicity are their major setbacks. Present work was focused on synthesizing colon-targeted prodrugs wherein MPA was bio-reversibly linked with aminosugars to mask carboxyl group of MPA responsible for gastrointestinal side effects. Synthesized prodrugs exhibited a significant mitigating outcome on 2,4,6-trinitrobezenesulfonic acid- induced colitis in Wistar rats compared to MPA. Absence of pancreatitis, hepatitis and gastro-sparing nature of the prodrugs emphasize their potential which could be reconnoitered further for management of IBD. |
| Publish Date |
2018-03-13 08:32 |
| Citation |
Choapade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i10.1093 |
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