Publication Name	World Journal of Gastroenterology
Manuscript ID	37488
Country	India

Received	2017-12-11 14:43
Peer-Review Started	2017-12-12 02:42
First Decision by Editorial Office Director	2017-12-26 20:27
Return for Revision	2017-12-27 09:31
Revised	2017-12-31 16:22
Publication Fee Transferred
Second Decision by Editor	2018-01-23 10:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-01-23 22:43
Articles in Press	2018-01-23 22:43
Edit the Manuscript by Language Editor	2018-02-07 03:32
Typeset the Manuscript	2018-03-09 09:48
Publish the Manuscript Online	2018-03-13 08:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats
Manuscript Source	Invited Manuscript
All Author List	Shakuntala Santosh Chopade and Suneela Sunil Dhaneshwar
ORCID	Author(s) ORCID Number Shakuntala Santosh Chopade http://orcid.org/orcid.org/0000-0002-3886-6577 Suneela Sunil Dhaneshwar http://orcid.org/000-0001-7646-642-X
Funding Agency and Grant Number	Funding Agency Grant Number Women Scientist Scheme-A (WOS-A) (DST) SR/WOS-A/ LS-1115/2014
Corresponding Author	Suneela Sunil Dhaneshwar, BPharm, PhD, Professor, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune 411038, India. suneeladhaneshwar@rediffmail.com
Key Words	Mycophenolic acid; Mutual prodrug; Inflammatory bowel disease; Mycophenolate mofetil
Core Tip	Mycophenolic acid (MPA), an immunosuppressant and its morpholinoethyl ester prodrug: mycophenolate mofetil are under investigation for the treatment of inflammatory bowel disease (IBD). Diarrhea and local gut toxicity are their major setbacks. Present work was focused on synthesizing colon-targeted prodrugs wherein MPA was bio-reversibly linked with aminosugars to mask carboxyl group of MPA responsible for gastrointestinal side effects. Synthesized prodrugs exhibited a significant mitigating outcome on 2,4,6-trinitrobezenesulfonic acid- induced colitis in Wistar rats compared to MPA. Absence of pancreatitis, hepatitis and gastro-sparing nature of the prodrugs emphasize their potential which could be reconnoitered further for management of IBD.
Publish Date	2018-03-13 08:32
Citation	Choapade SS, Dhaneshwar SS. Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats. World J Gastroenterol 2018; 24(10): 1093-1106
URL	http://www.wjgnet.com/1007-9327/full/v24/i10/1093.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i10.1093

Full Article (PDF)	WJG-24-1093.pdf
Full Article (Word)	WJG-24-1093.doc
The ARRIVE Guidelines	37488-ARRIVE Guidelines.pdf
Manuscript File	37488-Review.doc
Answering Reviewers	37488-Answering reviewers.pdf
Audio Core Tip	37488-Audio core tip.m4a
Biostatistics Review Certificate	37488-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	37488-Conflict-of-interest statement.pdf
Copyright License Agreement	37488-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	37488-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	37488-Institutional-Review-Board-Approval-Form-or-Document-revision.jpg
Non-Native Speakers of English Editing Certificate	37488-Language certificate.pdf
Peer-review Report	37488-Peer-review(s).pdf
Scientific Misconduct Check	37488-Scientific misconduct check.pdf
Scientific Editor Work List	37488-Scientific editor work list.pdf