| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
NOD2- and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn’s disease patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Holger Schaffler, Maria Rohde, Sarah Rohde, Astrid Huth, Hannes Hollborn, Nicole Gittel, Dirk Koczan, Änne Glass, Georg Lamprecht and Robert Jaster |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Damp-Foundation (2016-04) |
|
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| Corresponding Author |
Robert Jaster, MD, Academic Research, Professor, Senior Scientist, Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, Ernst-Heydemann-Str. 6, Rostock 18057, Germany. robert.jaster@med.uni-rostock.de |
| Key Words |
Peripheral blood mononuclear cells; Gene expression; NOD2; Lysozyme; Crohn’s disease; CLEC5A |
| Core Tip |
Peripheral blood mononuclear cells (PBMCs) are a useful tool to study peculiarities of the immune response in the context of Crohn’s disease (CD). Here, we investigated whether PBMCs from patients with CD, even at the stage of clinical remission, exhibit altered gene expression profiles after challenge with pathogen-associated molecular patterns and vitamin D. For TREM1, lysozyme and CLEC5A, disease-associated expression patterns, with higher transcript levels in patient-derived PBMCs, were observed. The two latter genes, along with four other transcripts, also showed NOD2-dependent expression profiles. TREM1 and CLEC5A may act with NOD2 in a regulatory network with a pathophysiological role in CD. |
| Publish Date |
2018-03-16 12:27 |
| Citation |
Schäffler H, Rohde M, Rohde S, Huth A, Gittel N, Hollborn H, Koczan D, Glass Ä, Lamprecht G, Jaster R. NOD2- and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn’s disease patients. World J Gastroenterol 2018; 24(11): 1196-1205 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i11/1196.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i11.1196 |
