Publication Name	World Journal of Gastroenterology
Manuscript ID	3763
Country	China

Received	2013-05-21 10:36
Peer-Review Started	2013-05-21 20:20
To Make the First Decision	2013-06-24 15:20
Return for Revision	2013-07-05 09:49
Revised	2013-07-04 20:43
Second Decision	2013-07-12 16:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-13 00:58
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-02 10:40
Publish the Manuscript Online	2013-08-19 18:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effects of SAHA on proliferation and apoptosis of hepatocellular carcinoma cells and hepatitis B virus replication
Manuscript Source	Invited Manuscript
All Author List	Ying-Chun Wang, Xu Yang, Lan-Hua Xing and Wei-Zong Kong
Funding Agency and Grant Number
Corresponding Author	Ying-Chun Wang, MD, Professor, Department of Gastroenterology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning Province, China. wych_1648@126.com
Key Words	Human hepatocellular carcinoma; HepG2.2.15 cells; Suberoylanilide hydroxamic acid; Hepatitis B virus
Core Tip	HepG2.2.15 cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA). Hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) content were measured using chemiluminescence. Reverse transcription polymerase chain reaction was performed to measure hepatitis B virus (HBV) DNA in cell lysate. Results found that, the inhibitory effect of SAHA on cell proliferation was both time- and dose-dependent. After 24 h of treatment, the early cell apoptotic rate increased. After 48 h of treatment, HBsAg and HBeAg content both increased. Furthermore, HBV DNA content increased. In combination with anti-HBV drugs, SAHA may potentially be used cautiously for treatment of hepatocellular carcinoma.
Publish Date	2013-08-19 18:22
Citation	Wang YC, Yang X, Xing LH, Kong WZ. Effects of SAHA on proliferation and apoptosis of hepatocellular carcinoma cells and hepatitis B virus replication. World J Gastroenterol 2013; 19(31): 5159-5164
URL	http://www.wjgnet.com/1007-9327/full/v19/i31/5159.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i31.5159

Full Article (PDF)	WJG-19-5159.pdf
Manuscript File	3763-Review.doc
Answering Reviewers	3763-Answering Reviewers.pdf
Copyright License Agreement	3763-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	3763-Language certificate.pdf
Peer-review Report	3763-Peer reviews.pdf
Scientific Editor Work List	3763-Scientific editor work list.doc