Publication Name	World Journal of Gastroenterology
Manuscript ID	37638
Country	China

Received	2017-12-24 07:10
Peer-Review Started	2017-12-25 01:31
To Make the First Decision	2018-01-04 06:11
Return for Revision	2018-01-04 09:39
Revised	2018-01-15 03:14
Second Decision	2018-01-18 11:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-01-18 15:04
Articles in Press	2018-01-18 15:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-30 20:43
Typeset the Manuscript	2018-02-21 04:26
Publish the Manuscript Online	2018-02-27 05:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Hui Wang, Ying He, Hong-Xian Wang, Cheng-Ling Liao, Yu Peng, Li-Jian Tao, Wei Zhang and Hui-Xiang Yang
ORCID	Author(s) ORCID Number Hong-Hui Wang http://orcid.org/0000-0003-0438-0234 Ying He http://orcid.org/0000-0002-5888-9696 Hong-Xian Wang http://orcid.org/0000-0001-7301-2625 Cheng-Ling Liao http://orcid.org/0000-0002-0457-4621 Yu Peng http://orcid.org/0000-0001-6953-7816 Li-Jian Tao http://orcid.org/0000-0003-0816-7588 Wei Zhang http://orcid.org/0000-0003-4774-6144 Hui-Xiang Yang http://orcid.org/0000-0001-5467-2927
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81370547 National Natural Science Foundation of China 81400642
Corresponding Author	Hui-Xiang Yang, MD, PhD, Professor, Department of Gastroenterology, Xiangya Hospital, Central South University,, 87 Xiangya Road,, Changsha 410008, Hunan Province, China. yang_hx430@csu.edu.cn
Key Words	NUDT15; TPMT; Azathioprine; Leukopenia; Inflammatory bowel disease; Individualized therapy
Core Tip	Azathioprine (AZA) plays an important role in the remission maintenance therapy of inflammatory bowel disease (IBD). However, serious drug adverse reactions, especially leukopenia, limit its clinical application. European consensus has identified TPMT polymorphism as a predictor of AZA-induced leukopenia. However, the predictive value of TPMT is controversial in Asians with low mutation rate and effectiveness. NUDT15 polymorphism has recently been found to be strongly associated with AZA-induced leukopenia in Asians but there are few data in Chinese populations. This study aimed to observe TPMT and NUDT15 polymorphisms and compare their predictive value for AZA-induced leukopenia in Chinese IBD patients.
Publish Date	2018-02-27 05:35
Citation	Wang HH, He Y, Wang HX, Liao CL, Peng Y, Tao LJ, Zhang W, Yang HX. Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2018; 24(8): 941-948
URL	http://www.wjgnet.com/1007-9327/full/v24/i8/941.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i8.941

Full Article (PDF)	WJG-24-941.pdf
Manuscript File	37638-Review.doc
Answering Reviewers	37638-Answering reviewers.pdf
Audio Core Tip	37638-Audio core tip.mp3
Biostatistics Review Certificate	37638-Biostatistics statement.pdf
Clinical Trial Registration Statement	37638-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	37638-Conflict-of-interest statement.pdf
Copyright License Agreement	37638-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37638-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	37638-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	37638-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	37638-Language certificate.pdf
Peer-review Report	37638-Peer-review(s).pdf
Scientific Misconduct Check	37638-Scientific misconduct check.pdf
Scientific Editor Work List	37638-Scientific editor work list.pdf