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6/4/2018 7:22:04 AM | Browse: 197 | Download: 75
Publication Name World Journal of Gastroenterology
Manuscript ID 37708
Country of Manuscript Source Denmark
2018-01-21 01:14
Peer-Review Started
2018-01-22 07:07
To Make the First Decision
2018-02-24 01:03
Return for Revision
2018-02-26 05:33
2018-03-08 21:53
Second Decision
2018-03-30 10:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-03-30 19:02
Articles in Press
2018-03-30 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-06-01 04:07
Publish the Manuscript Online
2018-06-04 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Case Report
Article Title Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature
Manuscript Source Unsolicited Manuscript
All Author List Christian Lodberg Hvas, Peter Ott, Peter Paine, Simon Lal, Søren Peter Jorgensen and Jens Frederik Dahlerup
Author(s) ORCID Number
Christian Lodberg Hvas http://orcid.org/0000-0001-7973-7184
Peter Ott http://orcid.org/0000-0002-3088-1983
Peter Paine http://orcid.org/0000-0003-4131-9651
Simon Lal http://orcid.org/0000-0002-6245-8864
Søren Peter Jorgensen http://orcid.org/0000-0002-6530-6655
Jens Frederik Dahlerup http://orcid.org/0000-0002-1587-7636
Funding Agency and Grant Number
Correspondence To Christian Lodberg Hvas, MD, PhD, Associate Professor, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark. chrishva@rm.dk
Keywords Bile acid malabsorption; Diarrhea; Farnesoid X-activated receptor; Crohn’s disease
Core Tip Bile acid diarrhea develops when excessive amounts of bile acids enter the terminal ileum and exceed the intestinal absorptive capacity. The excess bile acids enter the colon and cause secretory diarrhea. We report a patient with multiple potential causes of chronic diarrhea and suggest a systematic strategy for the diagnosis and treatment of this condition. Furthermore, we describe the use of a new treatment for severe bile acid diarrhea, obeticholic acid, which stimulates the farnesoid X receptor of the terminal ileum and increases fibroblast growth factor 19, thereby decreasing hepatic bile acid production via negative feedback.
Publish Date 2018-06-04 07:22
Citation Hvas CL, Ott P, Paine P, Lal S, Jørgensen SP, Dahlerup JF. Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature. World J Gastroenterol 2018; 24(21): 2320-2326
Url http://www.wjgnet.com/1007-9327/full/v24/i21/2320.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i21.2320
Full Article (PDF) WJG-24-2320.pdf
Full Article (Word) WJG-24-2320.doc
Manuscript File 37708-Review.docx
Answering Reviewers 37708-Answering reviewers.pdf
Audio Core Tip 37708-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 37708-Conflict-of-interest statement.pdf
Copyright License Agreement 37708-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 37708-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 37708-Language certificate.pdf
Peer-review Report 37708-Peer-review(s).pdf
Scientific Misconduct Check 37708-Scientific misconduct check.pdf
Scientific Editor Work List 37708-Scientific editor work list.pdf