BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/4/2018 7:22:04 AM | Browse: 1154 | Download: 1615
 |
Received |
|
2018-01-21 01:14 |
|
Peer-Review Started |
|
2018-01-22 07:07 |
|
To Make the First Decision |
|
2018-02-24 01:03 |
|
Return for Revision |
|
2018-02-26 05:33 |
|
Revised |
|
2018-03-08 21:53 |
|
Second Decision |
|
2018-03-30 10:08 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2018-03-30 19:02 |
|
Articles in Press |
|
2018-03-30 19:02 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2018-06-01 04:07 |
|
Publish the Manuscript Online |
|
2018-06-04 07:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Christian Lodberg Hvas, Peter Ott, Peter Paine, Simon Lal, Søren Peter Jorgensen and Jens Frederik Dahlerup |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Christian Lodberg Hvas, MD, PhD, Associate Professor, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Nørrebrogade 44, Aarhus C 8000, Denmark. chrishva@rm.dk |
| Key Words |
Bile acid malabsorption; Diarrhea; Farnesoid X-activated receptor; Crohn’s disease |
| Core Tip |
Bile acid diarrhea develops when excessive amounts of bile acids enter the terminal ileum and exceed the intestinal absorptive capacity. The excess bile acids enter the colon and cause secretory diarrhea. We report a patient with multiple potential causes of chronic diarrhea and suggest a systematic strategy for the diagnosis and treatment of this condition. Furthermore, we describe the use of a new treatment for severe bile acid diarrhea, obeticholic acid, which stimulates the farnesoid X receptor of the terminal ileum and increases fibroblast growth factor 19, thereby decreasing hepatic bile acid production via negative feedback. |
| Publish Date |
2018-06-04 07:22 |
| Citation |
Hvas CL, Ott P, Paine P, Lal S, Jørgensen SP, Dahlerup JF. Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature. World J Gastroenterol 2018; 24(21): 2320-2326 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i21/2320.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i21.2320 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
