Publication Name	World Journal of Gastroenterology
Manuscript ID	3785
Country	China

Received	2013-05-23 09:48
Peer-Review Started	2013-05-23 20:42
To Make the First Decision	2013-07-26 18:36
Return for Revision	2013-07-29 19:17
Revised	2013-08-20 23:13
Second Decision	2013-09-17 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-17 10:40
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-10-09 18:22
Typeset the Manuscript	2013-11-06 17:16
Publish the Manuscript Online	2013-12-18 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin
Manuscript Source	Invited Manuscript
All Author List	Mei-Fang Quan, Li-Hong Xiao, Zhi-Hong Liu, Hui Guo, Kai-Qun Ren, Fei Liu, Jian-Guo Cao and Xi-Yun Deng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81172375 Scientific Research Fund of Hunan Normal University 81105
Corresponding Author	Jian-Guo Cao, Professor, Medical College, Hunan Normal University, Yuelu District, Changsha 410013, Hunan Province, China. caojianguo2005@126.com
Key Words	Liver cancer; Cancer stem cell; 8-bromo-7-methoxychrysin; Self-renewal; β-catenin
Core Tip	We successfully obtained liver cancer stem cells (LCSCs) from the liver cancer MHCC97 cell line by employing the combination of magnetic activated cell sorting and tumorsphere culture. We showed for the first time that 8-bromo-7-methoxychrysin (BrMC), a synthetic analogue of chrysin, could preferentially inhibit proliferation and self-renewal, suppress epithelial-mesenchymal transition and invasion of LCSCs, and further eradicate LCSCs in vivo. The results of this study support the use of BrMC for liver cancer chemoprevention or chemotherapy.
Publish Date	2013-12-18 09:53
Citation	Quan MF, Xiao LH, Liu ZH, Guo H, Ren KQ, Liu F, Cao JG, Deng XY. 8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin. World J Gastroenterol 2013; 19(43): 7680-7695
URL	http://www.wjgnet.com/1007-9327/full/v19/i43/7680.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i43.7680

Full Article (PDF)	WJG-19-7680.pdf
Manuscript File	3785-Review.doc
Answering Reviewers	3785-Answering reviewers.pdf
Copyright License Agreement	3785-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Non-Native Speakers.doc
Peer-review Report	3785-Peer review(s).pdf
Scientific Editor Work List	3785-Scientific editor work list.doc