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Articles Published Processes
4/27/2018 3:25:40 AM | Browse: 1286 | Download: 1289
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Received |
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2018-01-17 01:02 |
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Peer-Review Started |
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2018-01-17 03:36 |
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To Make the First Decision |
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2018-02-10 08:57 |
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Return for Revision |
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2018-02-11 03:41 |
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Revised |
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2018-02-22 17:33 |
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Second Decision |
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2018-02-25 10:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-02-25 23:05 |
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Articles in Press |
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2018-02-25 23:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-04-25 11:12 |
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Publish the Manuscript Online |
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2018-04-27 03:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michelle L Boland, Stephanie Oldham, Brandon B Boland, Sarah Will, Jean-Martin Lapointe, Silvia Guionaud, Christopher J Rhodes and James L Trevaskis |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MedImmune |
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| Corresponding Author |
James L Trevaskis, BSc, PhD, Senior Scientist, Cardiovascular and Metabolic Diseases, MedImmune, LLC, 1 MedImmune Way, Gaithersburg, MD 20878, United States. trevaskisj@medimmune.com |
| Key Words |
Nonalcoholic steatohepatitis; Steatosis; Fibrosis; Mitochondrial function; Oxidative stress |
| Core Tip |
ob/ob and FATZO mice developed nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH) when fed a high trans-fat, high fructose and high cholesterol diet, in the context of obesity and insulin resistance, but showed differences in liver disease severity including collagen deposition and monocyte/macrophage infiltration. Mitochondrial dysfunction and increased numbers of mitochondria were observed in both models, similar to that reported in human NASH. Oxidative damage and antioxidant capacity were associated with disease severity. FATZO mice displayed increased catalase activity and reduced oxidative DNA damage compared to ob/ob mice, which may explain their lower disease burden. |
| Publish Date |
2018-04-27 03:25 |
| Citation |
Boland ML, Oldham S, Boland BB, Will S, Lapointe JM, Guionaud S, Rhodes CJ, Trevaskis JL. Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction. World J Gastroenterol 2018; 24(16): 1748-1765 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i16/1748.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i16.1748 |
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