| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori in Colombian populations
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Andrés Jenuer Matta, Diana Carolina Zambrano and Alvaro Jairo Pazos |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Administrative Department of Science and Innovation of the Republic of Colombia - COLCIENCIAS |
RC-1106-408-20549 |
| Registro Poblacional de Cáncer de Cali, Universidad del Valle, Cali, Colombia |
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| Corresponding Author |
Andrés Jenuer Matta, PhD, Academic Research, Department of Pathology, School of Medicine, Andres Jenuer Matta, MSc, PhD, Registro Poblacional de Cáncer de Cali, Department of Pathology, School of Medicine, Universidad del Valle, Street 4B No. 36-00, Building 116, Floor 4, Cali 760043, Colombia. <email>andres.matta@correounivalle.edu.co</email>, Universidad del Valle, Street 4B No 36-00, Building 116, Floor 4, 760043 Cali, Colombia. andres.matta@correounivalle.edu.co. Telephone: +57-2-5185623. Fax: +57-2-3212100. Ext 4101., Cali 760001, Valle del cauca, Colombia. andres.matta@correounivalle.edu.co |
| Key Words |
Clarithromycin; In vitro resistance; Point mutation; Helicobacter pylori; Gastric cancer; 23S rRNA |
| Core Tip |
Mutations in 23S rRNA gene V domain of Helicobacter pylori (H. pylori) were studied in order to determine their association with therapeutic failure. In clarithromycin-resistant H. pylori isolated from individuals at high-risk of gastric cancer (GC) in Túquerres-Colombia and at low-risk of GC in Tumaco-Colombia, mutations A1593T1, A1653G2, C1770T, C1954T1, and G1827C in isolates from Tumaco, and A2144G from Túquerres were found. Mutations T2183C and C2196T from both cities were not associated with clarithromycin resistance. However, therapeutic failure of eradication treatment in the sampled Colombian populations was associated with mutations of 23S rRNA gene in clarithromycin-resistant H. pylori. |
| Publish Date |
2018-04-11 08:28 |
| Citation |
Matta AJ, Zambrano DC, Pazos AJ. Punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori in Colombian populations. World J Gastroenterol 2018; 24(14): 1531-1539 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i14/1531.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i14.1531 |
