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Articles Published Processes
8/16/2018 11:54:24 AM | Browse: 873 | Download: 1363
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Received |
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2018-02-01 03:31 |
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Peer-Review Started |
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2018-02-02 01:05 |
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To Make the First Decision |
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2018-03-12 11:45 |
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Return for Revision |
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2018-03-15 07:10 |
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Revised |
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2018-03-29 02:20 |
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Second Decision |
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2018-06-07 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-06-08 02:08 |
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Articles in Press |
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2018-06-08 02:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-07-30 06:11 |
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Publish the Manuscript Online |
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2018-08-16 11:54 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Rong Xiao, Gui-Dan Xu, Wu-Jun Wei, Bin Peng and Yi-Bin Deng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81460123 |
| Guangxi Graduate Innovation Program |
201601005 |
| Guangxi Clinic Medicine Research Center of Hepatobiliary Disease |
AD17129025 |
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| Corresponding Author |
Yi-Bin Deng, PhD, Professor, Department of Medical Laboratory Science, the Affiliated Hospital of Youjiang Medical College for Nationalities, 18 Zhongshan 2nd Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. enbin0776@sina.com |
| Key Words |
Anti-gene therapy; Hepatitis B virus; Locked nucleic acid; Hepatitis B; Transgenic mice; Anti-sense-therapy |
| Core Tip |
We assess the antiviral effects of hepatitis B virus (HBV) S gene-specific anti-gene locked nucleic acid (LNA) in transgenic mice, to provide an experimental basis for gene therapy in patients with Chronic B-related Hepatitis. The inhibitory effect of anti-gene-LNA on serum HBV surface antigen (HBsAg) and HBV DNA peaked on day 7, with statistically significant differences compared with pre-treatment and control values. The mRNA levels of the HBVS gene and rates of HBsAg positive liver cells were significantly reduced compared with the control groups. |
| Publish Date |
2018-08-16 11:54 |
| Citation |
Xiao SR, Xu GD, Wei WJ, Peng B, Deng YB. Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice. World J Clin Cases 2018; 6(8): 183-191 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i8/183.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i8.183 |
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