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8/16/2018 11:54:24 AM | Browse: 336 | Download: 227
Publication Name World Journal of Clinical Cases
Manuscript ID 38083
Country/Territory China
Received
2018-02-01 03:31
Peer-Review Started
2018-02-02 01:05
To Make the First Decision
2018-03-12 11:45
Return for Revision
2018-03-15 07:10
Revised
2018-03-29 02:20
Second Decision
2018-06-07 09:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-08 02:08
Articles in Press
2018-06-08 02:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-07-30 06:11
Publish the Manuscript Online
2018-08-16 11:54
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice
Manuscript Source Unsolicited Manuscript
All Author List Shu-Rong Xiao, Gui-Dan Xu, Wu-Jun Wei, Bin Peng and Yi-Bin Deng
ORCID
Author(s) ORCID Number
Shu-Rong Xiao http://orcid.org/0000-0002-7408-7060
Gui-Dan Xu http://orcid.org/0000-0002-5388-6824
Wu-Jun Wei http://orcid.org/0000-0002-3706-3895
Bin Peng http://orcid.org/0000-0002-0081-5926
Yi-Bin Deng http://orcid.org/0000-0002-0869-0400
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81460123
Guangxi Graduate Innovation Program 201601005
Guangxi Clinic Medicine Research Center of Hepatobiliary Disease AD17129025
Corresponding author Yi-Bin Deng, PhD, Professor, Department of Medical Laboratory Science, the Affiliated Hospital of Youjiang Medical College for Nationalities, 18 Zhongshan 2nd Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. enbin0776@sina.com
Keywords Anti-gene therapy; Hepatitis B virus; Locked nucleic acid; Hepatitis B; Transgenic mice; Anti-sense-therapy
Core Tip We assess the antiviral effects of hepatitis B virus (HBV) S gene-specific anti-gene locked nucleic acid (LNA) in transgenic mice, to provide an experimental basis for gene therapy in patients with Chronic B-related Hepatitis. The inhibitory effect of anti-gene-LNA on serum HBV surface antigen (HBsAg) and HBV DNA peaked on day 7, with statistically significant differences compared with pre-treatment and control values. The mRNA levels of the HBVS gene and rates of HBsAg positive liver cells were significantly reduced compared with the control groups.
Publish Date 2018-08-16 11:54
Citation Xiao SR, Xu GD, Wei WJ, Peng B, Deng YB. Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice. World J Clin Cases 2018; 6(8): 183-191
Url http://www.wjgnet.com/2307-8960/full/v6/i8/183.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i8.183
Full Article (PDF) WJCC-6-183.pdf
Full Article (Word) WJCC-6-183.doc
Manuscript File 38083-Review.docx
Answering Reviewers 38083-Answering reviewers.pdf
Audio Core Tip 38083-Audio core tip.mp3
Biostatistics Review Certificate 38083-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38083-Conflict-of-interest statement.pdf
Copyright License Agreement 38083-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38083-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 38083-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 38083-Institutional Review Board Approval Form or Document.jpeg
Non-Native Speakers of English Editing Certificate 38083-Language certificate.pdf
Peer-review Report 38083-Peer-review(s).pdf
Scientific Misconduct Check 38083-Scientific misconduct check.pdf
Scientific Editor Work List 38083-Scientific editor work list.pdf