Publication Name	World Journal of Translational Medicine
Manuscript ID	3809
Country	United Kingdom

Received	2013-05-25 10:10
Peer-Review Started	2013-05-25 19:13
To Make the First Decision	2013-08-21 18:45
Return for Revision	2013-08-27 14:49
Revised	2013-09-07 00:50
Second Decision	2013-11-01 16:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-03 10:48
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-14 16:52
Publish the Manuscript Online	2014-01-06 20:25

ISSN	2220-6132 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Hypo-activity induced skeletal muscle atrophy and potential nutritional interventions: A review
Manuscript Source	Invited Manuscript
All Author List	Emma L Bostock, Christopher I Morse, Keith Winwood, Islay McEwan and Gladys L Onambélé-Pearson
Funding Agency and Grant Number
Corresponding Author	Gladys L Onambélé-Pearson, PhD, Institute for Performance Research, Department of Exercise and Sport Science, Manchester Metropolitan University, Crewe Green Road, Valentine Building, Room 2-7, Crewe CW1 5DU, United Kingdom. g.pearson@mmu.ac.uk
Key Words	Immobilisation; Disuse; Muscle size; Muscle strength; Nutrition supplementation; Muscle fatigability
Core Tip	This review summarises and compares the morphological, strength and fatigability changes in response to different models of hypo-activity. The hypo-activity models include de-training, bed-rest, immobilisation and unilateral lower limb suspension. There is a step-wise difference in the magnitude of muscle and somewhat strength losses so that, even after accounting for differential durations of interventions immobilisation ≥ unilateral lower limb suspension ≥ bed-rest ≥ de-training. Muscle fatigability varies between hypo-activity models but the results are equivocal and this may be due to task-specific adaptations. This review also highlights several potential nutritional interventions for attenuating hypo-activity induced changes.
Publish Date	2014-01-06 20:25
Citation	Bostock EL, Morse CI, Winwood K, McEwan I, Onambélé-Pearson GL. Hypo-activity induced skeletal muscle atrophy and potential nutritional interventions: A review. World J Transl Med 2013; 2(3): 36-48
URL	http://www.wjgnet.com/2220-6132/full/v2/i3/36.htm
DOI	http://dx.doi.org/10.5528/wjtm.v2.i3.36

Full Article (PDF)	WJTM-2-36.pdf
Full Article (Word)	WJTM-2-36.doc
Manuscript File	3809-Review.docx
Answering Reviewers	3809-Answering reviewers.pdf
Copyright License Agreement	3809-Copyright assignment.pdf
Peer-review Report	3809-Peer review(s).pdf
Scientific Editor Work List	3809-Scientific editor work list.doc