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7/12/2018 11:54:16 PM | Browse: 317 | Download: 155
Publication Name World Journal of Gastroenterology
Manuscript ID 38094
Country/Territory China
2018-03-29 07:18
Peer-Review Started
2018-03-30 07:06
To Make the First Decision
2018-05-17 03:14
Return for Revision
2018-05-21 02:45
2018-05-25 09:15
Second Decision
2018-06-08 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-09 04:35
Articles in Press
2018-06-09 04:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-06-19 20:01
Typeset the Manuscript
2018-07-09 07:53
Publish the Manuscript Online
2018-07-12 23:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Manuscript Source Unsolicited Manuscript
All Author List Yue Lu, Leng Li, Jin-Wei Zhang, Xiao-Qin Zhong, Jian-An Wei and Ling Han
Author(s) ORCID Number
Yue Lu http://orcid.org/0000-0002-5340-8398
Leng Li http://orcid.org/0000-0002-2011-7527
Jin-Wei Zhang http://orcid.org/0000-0003-2886-3222
Xiao-Qin Zhong http://orcid.org/0000-0002-2673-493X
Jian-An Wei http://orcid.org/0000-0003-1556-1321
Ling Han http://orcid.org/0000-0002-6168-8828
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81202635
Guangdong Provincial Bureau of Chinese Medicine 20151244
Corresponding author Ling Han, PhD, Research Scientist, The Second Clinical College, Guangzhou University of Chinese Medicine, Inner ring western road, University Town, Guangzhou 510006, Guangdong Province, China. linghan99@gzucm.edu.cn
Keywords Inflammatory bowel disease; tight junction; total polysaccharides of the Sijunzi decoction; Nuclear factor-κB pathway
Core Tip Total polysaccharides of the Sijunzi decoction (TPSJ) comprise the active ingredient of Sijunzi decoction, which has long been used to treat gastrointestinal tract disorders. However, the mechanisms by which TPSJ af­fects the intestinal epithelial barrier remain unclear. Our study results demonstrated that TPSJ attenuated tumor necrosis factor (TNF)-α-induced intestinal barrier dys­function in a Caco-2 cell monolayer. Furthermore, TPSJ inhibited TNF-α-induced upregulation of myosin light chain (MLC) phosphorylation, which is mediated by MLC kinase and NF-κB, suggesting that this mechanism might underlie the protective effects of TPSJ against intestinal epithelial barrier dysfunction triggered by proinflammatory cytokines.
Publish Date 2018-07-12 23:54
Citation Lu Y, Li L, Zhang JW, Zhong XQ, Wei JA, Han L. Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway. World J Gastroenterol 2018; 24(26): 2867-2877
Url http://www.wjgnet.com/1007-9327/full/v24/i26/2867.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i26.2867
Full Article (PDF) WJG-24-2867.pdf
Manuscript File 38094-Review.doc
Answering Reviewers 38094-Answering reviewers.pdf
Audio Core Tip 38094-Audio core tip.mp3
Biostatistics Review Certificate 38094-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38094-Conflict-of-interest statement.pdf
Copyright License Agreement 38094-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38094-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 38094-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 38094-Language certificate.pdf
Peer-review Report 38094-Peer-review(s).pdf
Scientific Misconduct Check 38094-Scientific misconduct check.pdf
Scientific Editor Work List 38094-Scientific editor work list.pdf