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Articles Published Processes
5/6/2018 1:12:00 PM | Browse: 1193 | Download: 1502
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Received |
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2018-01-26 01:37 |
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Peer-Review Started |
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2018-01-26 02:38 |
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To Make the First Decision |
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2018-02-05 01:12 |
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Return for Revision |
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2018-02-09 01:23 |
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Revised |
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2018-02-23 20:19 |
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Second Decision |
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2018-03-16 10:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-03-18 01:42 |
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Articles in Press |
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2018-03-18 01:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-03-28 07:53 |
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Typeset the Manuscript |
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2018-05-04 10:06 |
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Publish the Manuscript Online |
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2018-05-06 13:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Illona-Marie Boulete, Anusha Thadi, Catherine Beaufrand, Viren Patwa, Apoorva Joshi, John A Foss, E Priya Eddy, Helene Eutamene, Vaseem A Palejwala, Vassilia Theodorou and Kunwar Shailubhai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Synergy Pharmaceuticals Inc. |
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| Corresponding Author |
Kunwar Shailubhai, PhD, Professor, Baruch S. Blumberg Institute, 3805 Old Easton Rd, Doylestown, PA 18902, United States. shailu@synergypharma.com |
| Key Words |
Plecanatide; Guanylyl cyclase-C agonists; Dolcanatide; Uroguanylin; Preclinical; cyclic guanosine monophosphate; Constipation; Inflammatory bowel diseases |
| Core Tip |
Our results indicate that plecanatide and dolcanatide, guanylate cyclase-C receptor agonists designed to replicate the activity of the human intestinal peptide uroguanylin, maintain intestinal barrier function and exhibit potent anti-nociceptive activity in animal models of visceral hypersensitivity, suggesting a novel mechanism, beyond the well described secretory function, for these agonists in the treatment of functional constipation disorders and inflammatory bowel disease. |
| Publish Date |
2018-05-06 13:12 |
| Citation |
Boulete IM, Thadi A, Beaufrand C, Patwa V, Joshi A, Foss JA, Eddy EP, Eutamene H, Palejwala VA, Theodorou V, Shailubhai K. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol 2018; 24(17): 1888-1900 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i17/1888.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i17.1888 |
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