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Articles Published Processes
4/4/2018 1:15:45 PM | Browse: 1060 | Download: 1878
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Received |
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2018-01-28 04:40 |
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Peer-Review Started |
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2018-01-28 09:46 |
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To Make the First Decision |
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2018-02-10 08:33 |
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Return for Revision |
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2018-02-11 04:03 |
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Revised |
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2018-02-12 13:27 |
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Second Decision |
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2018-03-02 09:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-03-03 03:36 |
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Articles in Press |
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2018-03-03 03:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-03-14 21:20 |
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Typeset the Manuscript |
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2018-04-03 05:49 |
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Publish the Manuscript Online |
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2018-04-04 13:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You-Lan Chen, Ya-Li Zhang, Yan-Cheng Dai and Zhi-Peng Tang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Peng Tang, PhD, Doctor, Doctor, Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com |
| Key Words |
Ulcerative colitis; Ampelopsis grossedentata; Traditional Chinese medicine; Systems pharmacology; Inflammation |
| Core Tip |
Ulcerative colitis (UC), as one of the major forms of inflammatory bowel disease, could lead to various intestinal and extra-intestinal manifestations, which brings a huge challenge to the health care system. Given studies have confirmed that the flavonoid bioactive compounds contained in Ampelopsis grossedentata (AMP) possess strong antiinflammatory activity, we examined the potential therapeutic effects of AMP on UC based on systems pharmacology. Results showed that AMP could suppress the inflammation-related signaling pathways in dextran sulfate sodium-induced colitis, indicating protective effects on UC, which might provide an effective natural therapy for the treatment and prevention of UC. |
| Publish Date |
2018-04-04 13:15 |
| Citation |
Chen YL, Zhang YL, Dai YC, Tang ZP. Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis. World J Gastroenterol 2018; 24(13): 1398-1409 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i13/1398.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i13.1398 |
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