Publication Name	World Journal of Stem Cells
Manuscript ID	3814
Country	Iran

Received	2013-05-25 10:33
Peer-Review Started	2013-05-25 19:55
To Make the First Decision	2013-07-26 18:37
Return for Revision	2013-07-29 19:38
Revised	2013-08-27 16:54
Second Decision	2013-09-18 10:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-18 11:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-28 14:36
Typeset the Manuscript	2013-10-28 12:05
Publish the Manuscript Online	2013-10-31 14:50

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	Insulin producing cells established using non-integrated lentiviral vector harboring PDX1 gene
Manuscript Source	Invited Manuscript
All Author List	Zahra Niki Boroujeni and Ahmad Aleyasin
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of Genetic Engineering and Biotechnology, Ministry of Science Research and Technology, Tehran, Iran
Corresponding Author	Dr. Ahmad Aleyasin, DVM, MSc, PhD, Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran 14155-6343, Iran. sogand@nigeb.ac.ir
Key Words	Diabetes mellitus; Human adipose tissue derived stem cells; Non-integrated lentiviruses; PDX1; Insulin producing cells
Core Tip	Common treatments for diabetes mellitus are based on insulin injections and pancreas transplantation, limited by hypoglycemia, shortage of donors, immunosuppression and organ rejection. Cell therapy using human adipose tissue derived stem cells (hADSCs) offers a novel strategy for diabetes treatment without tumor formation and ethical concerns. Different viral vectors have been used for pancreatic differentiation. However, integration of provirus into host chromatin has induced insertional mutagenesis and malignancy. This is the first study to investigate the application of non-integrated Lentiviral vectors harboring PDX1 for differentiation of hADSCs into insulin producing cells and its usage in treatment of diabetic rats.
Publish Date	2013-10-31 14:50
Citation	Boroujeni ZN, Aleyasin A. Insulin producing cells established using non-integrated lentiviral vector harboring PDX1 gene. World J Stem Cells 2013; 5(4): 217-228
URL	http://www.wjgnet.com/1948-0210/full/v5/i4/217.htm
DOI	http://dx.doi.org/10.4252/wjsc.v5.i4.217

Full Article (PDF)	WJSC-5-217.pdf
Manuscript File	3814-Review.doc
Answering Reviewers	3814-Answering reviewers.pdf
Copyright License Agreement	3814-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	Language guarantee.docx
Peer-review Report	3814-Peer review(s).pdf
Scientific Editor Work List	3814-Scientific editor work list.doc