Publication Name	World Journal of Nephrology
Manuscript ID	38247
Country	Italy

Received	2018-02-02 22:47
Peer-Review Started	2018-02-05 01:45
First Decision by Editorial Office Director	2018-03-01 17:37
Return for Revision	2018-03-07 08:08
Revised	2018-03-12 17:45
Publication Fee Transferred
Second Decision by Editor	2018-04-19 00:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-04-22 17:43
Articles in Press	2018-04-22 17:43
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-04-29 04:49
Publish the Manuscript Online	2018-05-07 04:12

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement: Open challenges in the remission induction therapy
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Aris Tsalouchos
ORCID	Author(s) ORCID Number Maurizio Salvadori http://orcid.org/0000-0003-1503-2681 Aris Tsalouchos http://orcid.org/0000-0002-8565-4059
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Professor, Department of Nephrology and Renal Transplantation, Careggi University Hospital, viale Pieraccini 18, Florence 50139, Italy. maurizio.salvadori1@gmail.com
Key Words	Rapidly progressive glomerulonephritis; Remission induction therapy; Antineutrophil cytoplasmic antibody associated vasculitides; Cyclophosphamide; Rituximab; Corticosteroids; Plasma exchange; Avacopan
Core Tip	Antineutrophil cytoplasmic antibody (ANCA) associated vasculitides with renal involvement, presents as Rapidly Progressive Glomerulonephritis, are organ-threatening and potentially life-threatening diseases. Although remission induction immunosuppressive regimens overall have been very successful in the treatment of these conditions, many questions remain unanswered. The still open challenges and questions concern: (1) The choice of the first-line therapy (cyclophosphamide versus rituximab) based on renal function at baseline, new versus relapsed disease, ANCA specificity, tissue injury and safety; (2) the role of plasma exchange in combination with steroid and non steroid agents and (3) the advent of novel target therapies and strategies.
Publish Date	2018-05-07 04:12
Citation	Salvadori M, Tsalouchos A. Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement: Open challenges in the remission induction therapy. World J Nephrol 2018; 7(3): 71-83
URL	http://www.wjgnet.com/2220-6124/full/v7/i3/71.htm
DOI	http://dx.doi.org/10.5527/wjn.v7.i3.71

Full Article (PDF)	WJN-7-71.pdf
Full Article (Word)	WJN-7-71.doc
Manuscript File	38247-Review.docx
Answering Reviewers	38247-Answering reviewers.pdf
Audio Core Tip	38247-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	38247-Conflict-of-interest statement.pdf
Copyright License Agreement	38247-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	38247-Language certificate.pdf
Peer-review Report	38247-Peer-review(s).pdf
Scientific Editor Work List	38247-Scientific editor work list.pdf