| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu Wang, Song Wang, Zhen-Hua Liu, Wen-Qian Qi, Qian Zhang, Yong-Gui Zhang, De-Rong Sun, Yan Xu, Hong-Guang Wang, Zhongxie Li, Xian-Ling Cong, Ping Zhao, Chang-Yu Zhou and Jiang-Bin Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81670533 |
| Jilin Provincial Science & Technology Department |
2013 0102088JC |
| Jilin Provincial Development and Reform Commission |
2013C028-3 |
|
| Corresponding Author |
Jiang-Bin Wang, MD, PhD, Professor, Department of Digestive, China-Japan Union Hospital Affiliated to Jilin University, No.126 Xiantai Street, Changchun 130033, Jilin Province, China. zrlwangjb@163.com |
| Key Words |
Occult hepatitis C virus infection; CXCL10; Single nucleotide polymorphisms; rs1439490 |
| Core Tip |
We demonstrated that CXCL10 rs1439490 G/G was more prevalent in patients with seronegative occult hepatitis C virus infection (OCI) than in those with seropositive chronic hepatitis C virus (HCV) infection (CHC). Rs1439490 G/G OCI patients had lower serum and liver levels of CXCL10, and lower levels of liver necroinflammation and fibrosis than non-G/G patients. OCI patients had higher alanine aminotransferase normalization rates after Peg-interferon treatment than CHC patients and serum CXCL10 decreased significantly. We, for the first time, showed that CXCL10 rs1439490 G/G may be positively associated with OCI in HCV infection and antiviral outcome. |
| Publish Date |
2018-05-28 09:41 |
| Citation |
Wang X, Wang S, Liu ZH, Qi WQ, Zhang Q, Zhang YG, Sun DR, Xu Y, Wang HG, Li ZX, Cong XL, Zhao P, Zhou CY, Wang JB. Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection. World J Gastroenterol 2018; 24(20): 2191-2202 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i20/2191.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i20.2191 |
