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Articles Published Processes
9/6/2018 1:33:44 AM | Browse: 603 | Download: 833
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Received |
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2018-02-28 23:48 |
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Peer-Review Started |
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2018-03-01 01:36 |
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To Make the First Decision |
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2018-04-11 06:50 |
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Return for Revision |
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2018-04-18 03:14 |
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Revised |
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2018-06-14 02:01 |
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Second Decision |
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2018-06-15 07:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-06-16 06:08 |
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Articles in Press |
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2018-06-16 06:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-08-31 09:11 |
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Publish the Manuscript Online |
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2018-09-06 01:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michael Carsten Gock, Christina Mullins, Christine Harnack, F Prall, Robert Ramer, Anja Goeder, OH Kramer, E Klar and Michael Linnebacher |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Michael Linnebacher, PhD, Postdoc, Research Scientist, Department of General Surgery, Section of Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, Rostock 18055, Germany. michael.linnebacher@med.uni-rostock.de |
| Key Words |
Patient-derived tumor model; Large cell neuroendocrine carcinoma; Individualized medicine |
| Core Tip |
Since incidence of G3 poorly differentiated neuroendocrine carcinomas (NEC) is very low, data is substantially scarcer than on G1 or G2 neuroendocrine tumors. Herein we describe an ultra-low passage NEC cell line and corresponding patient-derived xenograft model established directly from patient derived colonic tumor samples. We characterized our model according to phenotype, molecular, morphological and growth characteristics, as well as drug response and radiation response profiles. We present a useful tool for further analysis of the biological characteristics and for development of novel diagnostic and therapeutic options for NEC. The model is available on request. |
| Publish Date |
2018-09-06 01:33 |
| Citation |
Gock M, Mullins CS, Harnack C, Prall F, Ramer R, Göder A, Krämer OH, Klar E, Linnebacher M. Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line. World J Gastroenterol 2018; 24(33): 3749-3759 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i33/3749.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i33.3749 |
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