Publication Name	World Journal of Gastroenterology
Manuscript ID	3857
Country	China

Received	2013-05-29 08:14
Peer-Review Started	2013-05-29 18:35
To Make the First Decision	2013-07-19 08:24
Return for Revision	2013-07-22 13:51
Revised	2013-09-11 14:42
Second Decision	2013-09-29 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-29 21:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-01 20:02
Typeset the Manuscript	2013-11-25 21:14
Publish the Manuscript Online	2013-12-18 10:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Rui Tian, Rui-Lan Wang, Hui Xie, Wei Jin and Kang-Long Yu
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Municipal Science and Technology Commission 114119b2900 Shanghai Municipal Key Laboratory of Pancreatic Disease P2012006
Corresponding Author	Rui-Lan Wang, MD, Intensive Care Unit, the First People′s Hospital, Shanghai Jiaotong University, 650 Xin Songjiang Road, Shanghai 201620, China. wangyusun@hotmail.com
Key Words	miRNA-155; Severe acute pancreatitis; Intestinal barrier dysfunction; Apical junctional complex
Core Tip	Apical junction complex (AJC) damage leads to intestinal barrier dysfunction and disease progression in severe acute pancreatitis (SAP) by an unknown mechanism. We reported for the first time that miRNA (miR)-155, a major mediator regulating early-stage inflammatory process, was overexpressed in experimental SAP intestinal epithelia as induced by circulating tumor necrosis factor (TNF)-α. RhoA gene, a predicted targeted gene for miR-155, was underexpressed at the post-transcriptional level, accompanied by downregulation of ZO-1 and E-cadherin expression; two key component proteins of AJC. Our study demonstrated that the TNF-α/miR-155/RhoA/ZO-1/E-cadherin signaling pathway contributed to intestinal barrier dysfunction in complicated SAP.
Publish Date	2013-12-18 10:39
Citation	Tian R, Wang RL, Xie H, Jin W, Yu KL. Overexpressed miRNA-155 dysregulates intestinal epithelial apical junctional complex in severe acute pancreatitis. World J Gastroenterol 2013; 19(45): 8282-8291
URL	http://www.wjgnet.com/1007-9327/full/v19/i45/8282.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i45.8282

Full Article (PDF)	WJG-19-8282.pdf
Manuscript File	3857-Review.doc
Answering Reviewers	3857-Answering reviewers.pdf
Copyright License Agreement	3857-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3857-Language certificate.pdf
Peer-review Report	3857-Peer review(s).pdf
Scientific Editor Work List	3857-Scientific editor work list.doc