Publication Name	World Journal of Transplantation
Manuscript ID	38578
Country	Italy

Received	2018-03-08 01:15
Peer-Review Started	2018-03-08 01:41
To Make the First Decision	2018-03-30 06:03
Return for Revision	2018-04-04 01:18
Revised	2018-04-09 18:11
Second Decision	2018-05-11 10:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-05-13 16:11
Articles in Press	2018-05-13 16:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-07 06:41
Publish the Manuscript Online	2018-08-09 08:05

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Observational Study
Article Title	Renal transplants from older deceased donors: Is pre-implantation biopsy useful? A monocentric observational clinical study
Manuscript Source	Invited Manuscript
All Author List	Giacomo Colussi, Costanza Casati, Valeriana Giuseppina Colombo, Mario Livio Pietro Camozzi and Fabio Rosario Salerno
ORCID	Author(s) ORCID Number Giacomo Colussi http://orcid.org/0000-0001-6133-1899 Costanza Casati http://orcid.org/0000-0002-7686-9920 Valeriana Giuseppina Colombo http://orcid.org/0000-0001-5813-6638 Mario Livio Pietro Camozzi http://orcid.org/0000-0003-2981-4748 Fabio Rosario Salerno http://orcid.org/0000-0002-2785-8125
Funding Agency and Grant Number
Corresponding Author	Giacomo Colussi, MD, Chief Doctor, Division of Nephrology, Dialysis and Renal Transplantatation, ASST Grande Ospedale Territoriale Niguarda, Piazza Ospedale Maggiore, 3, Milano 20162, Italy. giacomo.colussi@ospedaleniguarda.it
Key Words	Dual kidney transplant; Extended criteria donor; Graft survival; Pre-implantation biopsy score; Renal transplantation; Single kidney transplant
Core Tip	Pre-implantation biopsy of grafts from elderly donors is under appraisal as a means to direct the acceptance/discard decision of organs for transplanta­tion and the best allocation to single rather than dual transplant. Presented data shows that in recipients of grafts from older donors, rated suitable to donate according to clinical data and preserved renal function, graft and patient survival did not differ in the two ca­tegories of transplants with graft histological score in the lower (1-4) or higher (5-8) range of a scale in use. Additionally, allocation of higher score grafts to single or dual transplant did not result in different survival in time, but observed total number of dialysis free life years in recipients up to 6 years was lower for the dual kidney transplant (DKT) allocation. We suggest that older donors rated suitable to donation by clinical decision and preserved renal function may be allocated to single kidney transplant without biopsy; if biopsy is performed, higher scores than those in actual use should be consi­dered for allocation to DKT.
Publish Date	2018-08-09 08:05
Citation	Colussi G, Casati C, Colombo VG, Camozzi MLP, Salerno FR. Renal transplants from older deceased donors: Is pre-implantation biopsy useful? A monocentric observational clinical study. World J Transplant 2018; 8(4): 110-121
URL	http://www.wjgnet.com/2220-3230/full/v8/i4/110.htm
DOI	http://dx.doi.org/10.5500/wjt.v8.i4.110

Full Article (PDF)	WJT-8-110.pdf
Full Article (Word)	WJT-8-110.doc
STROBE Statement	38578-STROBE statement.pdf
Manuscript File	38578-Review.doc
Answering Reviewers	38578-Answering reviewers.pdf
Audio Core Tip	38578-Audio core tip.mp3
Biostatistics Review Certificate	38578-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	38578-Conflict-of-interest statement.pdf
Copyright License Agreement	38578-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	38578-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	38578-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	38578-Language certificate.pdf
Peer-review Report	38578-Peer-review(s).pdf
Scientific Editor Work List	38578-Scientific editor work list.pdf