Publication Name	World Journal of Gastroenterology
Manuscript ID	38588
Country	China

Received	2018-03-02 01:27
Peer-Review Started	2018-03-02 02:56
To Make the First Decision	2018-03-29 00:43
Return for Revision	2018-03-30 02:11
Revised	2018-04-04 00:34
Second Decision	2018-04-09 09:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-04-09 15:21
Articles in Press	2018-04-09 15:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-04-24 00:32
Typeset the Manuscript	2018-05-04 10:07
Publish the Manuscript Online	2018-05-06 13:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	Hepatic carcinoma; α-hederin; Apoptosis; Reactive oxygen species; Mitochondria
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells
Manuscript Source	Unsolicited Manuscript
All Author List	Jiao Li, Dan-Dan Wu, Ji-Xiang Zhang, Jing Wang, Jing-Jing Ma, Xue Hu and Wei-Guo Dong
ORCID	Author(s) ORCID Number Jiao Li http://orcid.org/0000-0002-4973-8255 Dan-Dan Wu http://orcid.org/0000-0003-2626-2861 Ji-Xiang Zhang http://orcid.org/0000-0002-8773-5020 Jing Wang http://orcid.org/0000-0001-7718-7254 Jing-Jing Ma http://orcid.org/0000-0002-5795-752X Xue Hu http://orcid.org/0000-0002-1918-2700 Wei-Guo Dong http://orcid.org/0000-0002-4228-6508
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81572426 Natural Science Foundation of Hubei Province 2015CKB755
Corresponding Author	Wei-Guo Dong, MD, PhD, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, 238 Jiefang Road,Wuchang,Wuhan, Wuhan 430060, Hubei Province, China. dongweiguo@whu.edu.cn
Key Words	Hepatic carcinoma; α-hederin; Apoptosis; Reactive oxygen species; Mitochondria
Core Tip	The α-hederin saponin induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo. We found that reactive oxygen species and the mitochondrial pathway play a vital role in α-hederin-induced apoptosis.
Publish Date	2018-05-06 13:12
Citation	Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X, Dong WG. Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells.World J Gastroenterol 2018; 24(17): 1901-1910
URL	http://www.wjgnet.com/1007-9327/full/v24/i17/1901.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i17.1901

Full Article (PDF)	WJG-24-1901.pdf
The ARRIVE Guidelines	38588-The ARRIVE guidelines.pdf
Manuscript File	38588-Review.docx
Answering Reviewers	38588-Answering reviewers.pdf
Audio Core Tip	38588-Audio core tip.mp3
Biostatistics Review Certificate	38588-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	38588-Conflict-of-interest statement.pdf
Copyright License Agreement	38588-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38588-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	38588-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	38588-Institutional-Review-Board-Approval-Form-or-Document-revision.png
Non-Native Speakers of English Editing Certificate	38588-Language certificate.pdf
Peer-review Report	38588-Peer-review(s).pdf
Scientific Misconduct Check	38588-Scientific misconduct check.pdf
Scientific Editor Work List	38588-Scientific editor work list.pdf