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7/5/2018 1:33:43 AM | Browse: 423 | Download: 249
Publication Name World Journal of Gastroenterology
Manuscript ID 38594
Country/Territory Belgium
Received
2018-03-05 16:03
Peer-Review Started
2018-03-06 07:50
To Make the First Decision
2018-03-14 00:32
Return for Revision
2018-03-17 08:27
Revised
2018-04-01 17:23
Second Decision
2018-04-09 09:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-09 15:20
Articles in Press
2018-04-09 15:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-04-24 00:38
Typeset the Manuscript
2018-07-03 03:46
Publish the Manuscript Online
2018-07-05 01:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers
Manuscript Source Unsolicited Manuscript
All Author List Ye-Wei Liu, Frederik De Keyzer, Yuan-Bo Feng, Feng Chen, Shao-Li Song, Johan Swinnen, Guy Bormans, Raymond Oyen, Gang Huang and Yi-Cheng Ni
ORCID
Author(s) ORCID Number
Ye-Wei Liu http://orcid.org/0000-0002-4360-0132
Frederik De Keyzer http://orcid.org/0000-0002-1855-3274
Yuan-Bo Feng http://orcid.org/0000-0002-4235-3491
Feng Chen http://orcid.org/0000-0001-8490-0054
Shao-Li Song http://orcid.org/0000-0003-2544-7522
Johan Swinnen http://orcid.org/0000-0002-7720-5077
Guy Bormans http://orcid.org/0000-0002-0335-7190
Raymond Oyen http://orcid.org/0000-0003-2256-5910
Gang Huang http://orcid.org/0000-0003-1939-3978
Yi-Cheng Ni http://orcid.org/0000-0002-8553-7565
Funding Agency and Grant Number
Corresponding author Gang Huang, MD, PhD, Full Professor, Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Zhouzhu Road 279, Shanghai 200318, China. huangsumhs@163.com
Keywords Hepatocellular carcinoma; Combretastatin A4 phosphate; Rhabdomyosarcoma; Vascular-disrupting agent; Magnetic resonance imaging; Rats
Core Tip Complex animal models combining primary and secondary liver malignancies proved feasible in rats. The therapeutic efficacy of the leading vascular disrupting agent combretastatin-A4-phosphate (CA4P) could be intra-individually compared between primary and secondary liver malignancies in the same cirrhotic rats. Clinical 3.0T magnetic resonance imaging allowed real-time monitoring of in vivo therapeutic responses within 12 h, and ex vivo microangiography and histopathology could validate the CA4P-induced tumoricidal effects. The therapeutic responses appeared superior with secondary liver tumors over that with primary hepatocellular carcinomas, which are of translational significance for planning future clinical trials of CA4P in cancer patients.
Publish Date 2018-07-05 01:33
Citation Liu YW, De Keyper F, Feng YB, Chen F, Song SL, Swinnen J, Bormans G, Oyen R, Huang G, Ni YC. Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers. World J Gastroenterol 2018; 24(25): 2710-2721
Url http://www.wjgnet.com/1007-9327/full/v24/i25/2710.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i25.2710
Full Article (PDF) WJG-24-2710.pdf
Full Article (Word) WJG-24-2710.doc
Manuscript File 38594-Review.docx
Answering Reviewers 38594-Answering reviewers.pdf
Audio Core Tip 38594-Audio core tip.m4a
Biostatistics Review Certificate 38594-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38594-Conflict-of-interest statement.pdf
Copyright License Agreement 38594-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 38594-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 38594-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 38594-Language certificate.pdf
Peer-review Report 38594-Peer-review(s).pdf
Scientific Misconduct Check 38594-Scientific misconduct check.pdf
Scientific Editor Work List 38594-Scientific editor work list.pdf