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Articles Published Processes
7/5/2018 1:33:43 AM | Browse: 1057 | Download: 1140
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Received |
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2018-03-05 16:03 |
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Peer-Review Started |
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2018-03-06 07:50 |
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To Make the First Decision |
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2018-03-14 00:32 |
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Return for Revision |
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2018-03-17 08:27 |
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Revised |
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2018-04-01 17:23 |
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Second Decision |
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2018-04-09 09:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-04-09 15:20 |
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Articles in Press |
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2018-04-09 15:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-04-24 00:38 |
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Typeset the Manuscript |
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2018-07-03 03:46 |
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Publish the Manuscript Online |
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2018-07-05 01:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ye-Wei Liu, Frederik De Keyzer, Yuan-Bo Feng, Feng Chen, Shao-Li Song, Johan Swinnen, Guy Bormans, Raymond Oyen, Gang Huang and Yi-Cheng Ni |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Gang Huang, MD, PhD, Full Professor, Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Zhouzhu Road 279, Shanghai 200318, China. huangsumhs@163.com |
| Key Words |
Hepatocellular carcinoma; Combretastatin A4 phosphate; Rhabdomyosarcoma; Vascular-disrupting agent; Magnetic resonance imaging; Rats |
| Core Tip |
Complex animal models combining primary and secondary liver malignancies proved feasible in rats. The therapeutic efficacy of the leading vascular disrupting agent combretastatin-A4-phosphate (CA4P) could be intra-individually compared between primary and secondary liver malignancies in the same cirrhotic rats. Clinical 3.0T magnetic resonance imaging allowed real-time monitoring of in vivo therapeutic responses within 12 h, and ex vivo microangiography and histopathology could validate the CA4P-induced tumoricidal effects. The therapeutic responses appeared superior with secondary liver tumors over that with primary hepatocellular carcinomas, which are of translational significance for planning future clinical trials of CA4P in cancer patients. |
| Publish Date |
2018-07-05 01:33 |
| Citation |
Liu YW, De Keyper F, Feng YB, Chen F, Song SL, Swinnen J, Bormans G, Oyen R, Huang G, Ni YC. Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers. World J Gastroenterol 2018; 24(25): 2710-2721 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i25/2710.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i25.2710 |
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